Synthesis and Evaluation of Glucosyl-, Acyl- and Silyl- Resveratrol Derivatives as Retinoprotective Agents: Piceid Octanoate Notably Delays Photoreceptor Degeneration in a Retinitis Pigmentosa Mouse Model

被引：0

作者：

Valdes-Sanchez, Lourdes ^{[1
]}

Moshtaghion, Seyed Mohamadmehdi ^{[1
]}

Caballano-Infantes, Estefania ^{[1
]}

Penalver, Pablo ^{[2
]}

Rodriguez-Ruiz, Rosario ^{[2
]}

Gonzalez-Alfonso, Jose Luis ^{[3
]}

Plou, Francisco Jose ^{[3
]}

Desmet, Tom ^{[4
]}

Morales, Juan C. ^{[2
]}

Diaz-Corrales, Francisco J. ^{[1
]}

机构：

[1] Univ Pablo Olavide, Univ Sevilla, Andalusian Mol Biol & Regenerat Med Ctr CABIMER, Dept Integrat Pathophysiol & Therapies,Junta Andal, Avda Americo Vespucio 24, Seville 41092, Spain

[2] CSIC, Inst Parasitol & Biomed Lopez Neyra, Dept Biochem & Mol Pharmacol, PTS Granada, Avda Conocimiento 17, Granada 18016, Spain

[3] CSIC, Inst Catalisis & Petroleoquim, Marie Curie 2, Madrid 28049, Spain

[4] Univ Ghent, Ctr Synthet Biol, Dept Biotechnol, Coupure Links 653, B-9000 Ghent, Belgium

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 11期

关键词：

neurodegeneration; retinal degeneration; retinitis pigmentosa; resveratrol; piceid octanoate; retinoprotection; RETINAL DEGENERATION; PRODRUGS; BIOAVAILABILITY; INFLAMMATION; CARBONYL; ANALOGS; STRESS; CELLS;

D O I：

10.3390/ph17111482

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Retinitis pigmentosa (RP), the leading cause of inherited blindness in adults, is marked by the progressive degeneration of rod photoreceptors in the retina. While gene therapy has shown promise in treating RP in patients with specific mutations, no effective therapies currently exist for the majority of patients with diverse genetic backgrounds. Additionally, no intervention can yet prevent or delay photoreceptor loss across the broader RP patient population. Resveratrol (RES), a naturally occurring polyphenol, has shown cytoprotective effects in various neurodegenerative disease models; however, its therapeutic potential is limited by low bioavailability. Methods: In this study, we synthesized novel RES derivatives and assessed their retinoprotective effects in a murine model of RP (rd10 mice). Results: Among these derivatives, piceid octanoate (PIC-OCT) significantly delayed photoreceptor degeneration in the RP model, demonstrating superior efficacy compared to RES. Conclusions: PIC-OCT shows strong potential as a leading candidate for developing new therapeutic strategies for RP.

引用

页数：21