Synthesis of 2-Phosphonylated C3 Spirocyclic Indolines via a Dearomatization-Spirocyclization-Nucleophilic Addition Tandem Approach of Indolyl-ynones with Phosphine Oxides

被引：0

作者：

Duan, Jiongjiong ^{[1
]}

Cao, Yi ^{[1
]}

Xie, Huanping ^{[1
]}

Yu, Yongqi ^{[1
]}

Sheng, Heyun ^{[1
]}

Kong, Weiguang ^{[1
]}

Li, Ting ^{[1
]}

机构：

[1] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Nanyang 473061, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 90卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SELECTIVE SYNTHESIS; ACCESS;

D O I：

10.1021/acs.joc.4c02364

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Due to its unique three-dimensional (3D) configuration and great application potential in medicinal chemistry and synthetic community, chemists have been pursuing concise and efficient methods to synthesize C3 spirocyclic indoline derivatives. In this work, a dearomatization-spirocyclization-nucleophilic addition tandem approach was developed to realize the synthesis of 2-phosphonylated C3 spirocyclic indolines with indolyl-ynones and phosphine oxides as reactants; mild conditions, broad substrate scope, and good yields are characteristics of this transformation.

引用

页码：428 / 438

页数：11