A new 14-membered cembrane-type diterpenoid and other constituents from the aerial parts of Jatropha integerrima Jacq. and their antibacterial activity

A new 14-membered cembrane-type diterpenoid, jatrophainolide D (1), along with six known compounds, (E)-phytol (2), lupeol (3), stigmasterol (4), ergosta-4,6,8 (14),22-tetraen-3-one (5), stigmast-4-ene-3-one (6), and ergosterol peroxide (7) were isolated from the aerial parts of Jatropha integerrima. The structure of isolates was elucidated by IR, UV, 1D-/2D-NMR, and HRESI-TOFMS data as well as by comparison with the reported spectroscopic data. All isolates were evaluated the antibacterial activity against S. enterica, E. coli, P. aeruginosa, E. faecalis, B. cereus, and S. aureus. Diterpenoids 1 and 2 exhibited antibacterial activity against all reference bacterial strains with MIC values ranging from 128 to 512 mu g/mL. Meanwhile, steroids 3-7 displayed selective antibacterial activities against the tested strains. These findings suggest that J. integerrima revealed promise for additional comprehensive investigations into plant-derived compounds in the development of antibacterial drugs.