CRISPR-Cas12a gene editing with linear single-stranded DNA repair templates with end modifications enables highly efficient knock-ins of therapeutic transgenes in primary human T cells

被引:0
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作者
Nitulescu, A. M. [1 ,2 ,3 ,4 ]
Du, W. [1 ,2 ,3 ,4 ]
Glaser, V. [1 ,2 ,3 ,4 ]
Kath, J. [1 ,2 ,3 ,4 ]
Wagner, D. L. [1 ,2 ,3 ,4 ]
机构
[1] Charite Univ Med Berlin, Berlin Ctr Adv Therapies BeCAT, Berlin, Germany
[2] Humboldt Univ, Freie Univ Berlin, Berlin, Germany
[3] Berlin Inst Hlth BIH, Berlin, Germany
[4] Charite Univ Med Berlin, Berlin Inst Hlth BIH, BIH Ctr Regenerat Therapies BCRT, Berlin, Germany
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中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
P681
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页码:A281 / A282
页数:2
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