ENHANCEMENT OF ACYL COENZYME-A - RETINOL ACYLTRANSFERASE IN RAT-LIVER AND MAMMARY-TUMOR TISSUE BY RETINYL ACETATE AND ITS COMPETITIVE-INHIBITION BY N-(4-HYDROXYPHENYL)RETINAMIDE

被引：32

作者：

BALL, MD ^{[1
]}

FURR, HC ^{[1
]}

OLSON, JA ^{[1
]}

机构：

[1] IOWA STATE UNIV SCI & TECHNOL, DEPT BIOCHEM & BIOPHYS, AMES, IA 50011 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1985年 / 128卷 / 01期

关键词：

D O I：

10.1016/0006-291X(85)91636-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinol esterification by microsomal acyl CoA:retinol acyltransferase was quantified in rat mammary tumor and liver tissue. Acyltransferase activity in the livers of mammary tumor-bearing rats was 40% of that in normal animals. In response to daily oral doses of 2 mg retinyl acetate for 18-19 days, activity increased 2.8-fold in transplanted rat mammary tumors, 4.1-fold in the livers of tumor-bearing rats and 1.5-fold in the livers of normal rats. The in vitro esterification of retinol was competitively inhibited by all trans-N-(4-hydroxyphenyl)retinamide (Ki = 154 .mu.M).

引用

页码：7 / 11

页数：5

共 3 条

[1] N-(4-hydroxyphenyl)-retinamide increases lecithin: Retinol acyltransferase activity in rat liver
Matsuura, T
Zhao, Z
Ross, AC
JOURNAL OF NUTRITION, 1996, 126 (10): : 2474 - 2480
[2] CHEMOTHERAPEUTIC EVALUATION OF GLUCARATE AND N-(4-HYDROXYPHENYL)RETINAMIDE ALONE AND IN COMBINATION IN THE RAT MAMMARY-TUMOR MODEL
ABOUISSA, H
WEBB, TE
MINTON, JP
MOESCHBERGER, M
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (23) : 1820 - 1823
[3] N-(4-HYDROXYPHENYL)RETINAMIDE (HPR, FENRETINIDE) INCREASES INTACT APO-RETINOL-BINDING PROTEIN IN RAT-LIVER
BOORNAZIAN, ML
SMITH, JE
FASEB JOURNAL, 1993, 7 (03): : A302 - A302

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