CuS@Ag Heterostructure-based Surface Plasmonic Coupling Electrochemiluminescence Sensor for Glioma miRNA-124-3p Detection

被引:0
|
作者
Li, Wenyan [1 ]
Liang, Zihui [1 ]
Wang, Peilin [1 ]
Li, Zhenrun [1 ]
Ma, Qiang [1 ]
机构
[1] Jilin Univ, Coll Chem, Dept Analyt Chem, Changchun 130012, Peoples R China
来源
基金
中国国家自然科学基金;
关键词
Aggregation-induced; electrochemiluminescence; Covalent organic frameworks; Surface plasmonic coupling effect; miRNA-124-3p detection; Glioma diagnosis; FRAMEWORK; THERAPY;
D O I
10.1016/j.bios.2025.117202
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
As an emerging class of extended crystalline organic materials, covalent organic framework (COF)-based aggregation-induced emission luminogen (AIE-gen) exhibited encouraging emissive properties. In this work, 4',4",4 & tprime;,4 & tprime;'-(1,1,2,2-Ethenetetrayl)tetra(4-biphenylcarbaldehyde) (ETBC) as AIEgen was used to prepare AIECOF (ET-COF-COOH) luminescent nanoprobe. ETBC and 1,3,5-Tris(4-aminophenyl)benzene (TAPB) had an extended it electronic system that allowed electron delocalization and overlapping transport. Because AIEgenETBC served as the luminescence center of ET-COF-COOH, the ET-COF-COOH possessed an ideal anodic electrochemiluminescence (ECL) performance. Moreover, due to the surface plasmonic coupling (SPC) effect of the CuS@Ag square-cavity array, the ECL signal of ET-COF-COOH was amplified as 2.8 times. The AIE-COF/CuS@Ag SCH array-based SPC-ECL sensor was used to detect miRNA-124-3p with a wide range of 1 fM-10 nM and LOD of 0.49 fM. Furthermore, the proposed biosensor can effectively distinguish between tumor tissue and adjacent tissue and offer significant potential for advancing glioma diagnosis.
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页数:8
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