Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography

被引：0
|
作者：
Neubrand, Linda B. [1 ,2 ,3 ]
Attendu, Xavier [1 ,2 ,3 ,4 ]
van Leeuwen, Ton G. [1 ,2 ,3 ]
机构：
[1] Locat Univ Amsterdam, Dept Biomed Engn & Phys, Amsterdam UMC, Amsterdam, Netherlands
[2] Amsterdam Cardiovasc Sci, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands
[3] Canc Ctr Amsterdam, Imaging & Biomarkers, Amsterdam, Netherlands
[4] Polytech Montreal, Ctr Opt Photon & Lasers, Dept Engn Phys, Montreal, PQ, Canada
来源：
JOURNAL OF BIOPHOTONICS | 2025年 / 18卷 / 03期
关键词：
attenuation coefficient; Cram & eacute; r-Rao lower bound; curve-fitting; depth-resolved estimation; Fisher matrix; optical coherence tomography; precision; SPECKLE REDUCTION; SCATTERING;
D O I：
10.1002/jbio.202400395
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm-1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.
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页数：14
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