Assessment of beta-cell functionality and toxicity identification of mouse beta-cell line Min6 2D model and primary human islet 3D model as useful in vitro tools

被引：0
|
作者：
Thulin, P. [1 ]
Pettersson, M. [1 ]
Boyd, F. [1 ]
Persson, M. [1 ]
Forsgard, M. [1 ]
机构：
[1] AstraZeneca R&D, Clin Pharmacol & Safety Sci, Gothenburg, Sweden
来源：
TOXICOLOGY LETTERS | 2024年 / 399卷
关键词：
D O I：
10.1016/j.toxlet.2024.07.226
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
P01-35
引用
收藏
页码：S85 / S85
页数：1
相关论文
共 48 条
  • [1] Assessment of endocrine pancreas toxicity - identification of mechanisms of toxicity using Min6 mouse beta-cell model
    Forsgard, M.
    Boyd, F.
    Pettersson, M.
    Persson, M.
    Thulin, P.
    TOXICOLOGY LETTERS, 2024, 399 : S81 - S82
  • [2] Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells
    Zhao, Yu-Feng
    Wang, Li
    Lee, Soohyun
    Sun, Qiang
    Tuo, Ya
    Wang, Yuemin
    Pei, Jianming
    Chen, Chen
    ENDOCRINE, 2010, 37 (01) : 76 - 82
  • [3] Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells
    Yu-Feng Zhao
    Li Wang
    Soohyun Lee
    Qiang Sun
    Ya Tuo
    Yuemin Wang
    Jianming Pei
    Chen Chen
    Endocrine, 2010, 37 : 76 - 82
  • [4] THE EFFECT OF ER STRESS ON TRANSLATION INITIATION FACTOR COMPETENCY IN THE MOUSE PANCREATIC BETA-CELL LINE MIN6
    Elfowiris, A.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2020, 22 : A183 - A184
  • [5] GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6
    Tomonari, A
    Yoshimoto, K
    Tanaka, M
    Iwahana, H
    Miyazaki, J
    Itakura, M
    DIABETOLOGIA, 1996, 39 (12) : 1462 - 1468
  • [6] A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes
    Parilla, Jacqueline H.
    Willard, Joshua R.
    Barrow, Breanne M.
    Zraika, Sakeneh
    JOURNAL OF DIABETES RESEARCH, 2018, 2018
  • [7] Possible Implication of Cyclin D2 in Beta-Cell Proliferation of Human Perinatal Islet
    Osonoi, Sho
    Ichinohe, Hiroshi
    Kudo, Kazuhiro
    Yagihashi, Soroku
    Mizukami, Hiroki
    DIABETES, 2020, 69
  • [8] Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6
    Nakazaki, M
    Ishihara, H
    Kakei, M
    Inukai, K
    Asano, T
    Miyazaki, JI
    Tanaka, H
    Kikuchi, M
    Yada, T
    Oka, Y
    DIABETOLOGIA, 1998, 41 (03) : 279 - 286
  • [9] Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6
    M. Nakazaki
    H. Ishihara
    M. Kakei
    K. Inukai
    T. Asano
    J.-I. Miyazaki
    H. Tanaka
    M. Kikuchi
    T. Yada
    Y. Oka
    Diabetologia, 1998, 41 : 279 - 286
  • [10] Differentiation of Human Pluripotent Stem Cells into Pancreatic Beta-cell Precursors in a 2D Culture System
    Memon, Bushra
    Abdelalim, Essam M.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, (178):
12345