Associations of plasma extracellular microRNAs with new-onset breast cancer in the Framingham heart study

被引：0
|
作者：
Karlin, Hannah [1 ,2 ]
Larson, Martin [1 ,3 ]
Rong, Jian [1 ,4 ]
Huan, Tianxiao [1 ,2 ,5 ]
Courchesne, Paul [1 ,2 ]
Freedman, Jane E. [6 ]
Ho, Jennifer E. [1 ,7 ,8 ]
Tanriverdi, Kahraman [6 ]
Mueller, Gregory P. [9 ]
Levy, Daniel [1 ,2 ,10 ,11 ]
机构：
[1] Framingham Heart Dis Epidemiol Study, Framingham, MA USA
[2] NHLBI, Populat Sci Branch, NIH, Bethesda, MD USA
[3] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
[4] Boston Univ, Chobanian & Avedisian Sch Med, Dept Neurol, Boston, MA USA
[5] Univ Massachusetts, Med Sch, Dept Ophthalmol & Visual Sci, Worcester, MA USA
[6] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med, Nashville, TN USA
[7] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA
[8] Harvard Med Sch, Boston, MA USA
[9] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD USA
[10] Boston Univ, Sch Med, Boston, MA USA
[11] NHLBI Framingham Heart Study, 73 Mt Wayte Ave,Suite 2, Framingham, MA 01702 USA
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2024年 / 14卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Breast cancer; microRNA; extracellular RNA; biomarker; risk factors;
D O I：
10.62347/KMFI7371
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the second leading cause of cancer deaths among women. Multiple microRNAs (miRNAs) have been reported to be associated with breast cancer progression or metastasis. The purpose of the current study was to identify plasma extracellular miRNAs associated with incident breast cancer. Levels of 166 plasma miRNA were measured using qRT-PCR in 2140 Framingham Heart Study female participants with a median follow up of 15.7 years. Prospective analyses of the associations of miRNAs with the occurrence of 56 new-onset breast cancer events were conducted using proportional hazards regression. The expression levels miR-134-5p (P=0.002) and miR-505-3p (P=0.005) were found to be positively associated with incident breast cancer after adjusting for age, body mass index, and cigarette smoking. These results highlight plasma miRNAs as potential biomarkers of breast cancer risk. Validation of these findings in larger and more diverse cohorts is warranted.
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页数：9
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