[1] Assoc Invest Biomed & Inovacao Luz & Imagem, Coimbra, Portugal
[2] CORC Coimbra Ophthalmol Reading Ctr, Coimbra, Portugal
[3] Univ Aveiro, Dept Matemat, Aveiro, Portugal
[4] Hosp Univ Coimbra, Ctr Hosp & Univ Coimbra, Neurol Dept, EPE Campus, Coimbra, Portugal
[5] Boehringer Ingelheim Int GmbH, Ingelheim, Rheinland Pfalz, Germany
[6] Univ Coimbra, Fac Med, Inst Invest Clin & Biomed Coimbra, Coimbra, Coimbra, Portugal
[7] Boehringer Ingelheim Int GmbH, Ridgefield, CT USA