An efficient direct electrolysis method for the synthesis of 1,1,1,3,3,3-hexafluoroisopropyxy substituted imidazo[1,2-a]pyridines

被引：0

作者：

Kong, Yanyan ^{[1
,2
]}

Gong, Ming ^{[2
]}

Xu, Xuemei ^{[1
]}

Wu, Yangjie ^{[2
]}

Jiang, Xingmao ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Chem Engn & Pharm, Hubei Key Lab Novel Chem Reactor & Green Chem Tech, Key Lab Green Chem Proc,Minist Educ, Wuhan 430073, Peoples R China

[2] Zhengzhou Univ, Key Lab Appl Chem Henan Univ, Coll Chem, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 09期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d4ob02073a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Electrochemical oxidative cross-dehydrogenative-coupling (CDC) is an ideal strategy to conduct the C3-alkoxylation of imidazo[1,2-a]pyridine, but it remains a challenge owing to limitation imposed by the use of alkyl alcohols and carboxylic acids. Herein, we report a mild and efficient 2-electrode constant-potential electrolysis of imidazo[1,2-a]pyridine with hexafluoroisopropanol (HFIP) to produce various imidazo[1,2-a]pyridine HFIP ethers. Mechanistic studies indicated that the electrooxidation reaction might involve radical coupling and ionic reaction.

引用

页码：2190 / 2194

页数：5

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