Diagnostic performance of attenuation imaging versus controlled attenuation parameter for hepatic steatosis with MRI-based proton density fat fraction as the reference standard: a prospective multicenter study

被引:0
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作者
Nishimura, Takashi [1 ,2 ]
Tada, Toshifumi [3 ]
Akita, Tomoyuki [4 ]
Kondo, Reiichiro [5 ]
Suzuki, Yasuaki [6 ]
Imajo, Kento [7 ,8 ]
Kokubu, Shigehiro [8 ]
Abe, Tamami [9 ]
Kuroda, Hidekatsu [9 ]
Hirooka, Masashi [10 ]
Hiasa, Yoichi [10 ]
Nogami, Asako [7 ]
Nakajima, Atsushi [7 ]
Ogawa, Sadanobu [11 ]
Toyoda, Hidenori [12 ]
Oeda, Satoshi [13 ,14 ]
Takahashi, Hirokazu [13 ]
Eguchi, Yuichiro [13 ]
Sugimoto, Katsutoshi [15 ]
Yano, Hirohisa [5 ]
Tanaka, Junko [4 ]
Moriyasu, Fuminori [16 ]
Kage, Masayoshi [17 ]
Kumada, Takashi [18 ]
Iijima, Hiroko [1 ,2 ]
机构
[1] Hyogo Med Univ, Dept Gastroenterol, Div Hepatobiliary & Pancreat Dis, 1-1 Mukogawa Cho, Nishinomiya, Japan
[2] Hyogo Med Univ, Ultrasound Imaging Ctr, Nishinomiya, Hyogo, Japan
[3] Japanease Red Cross Himeji Hosp, Dept Internal Med, Himeji, Hyogo, Japan
[4] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Epidemiol Infect Dis Control & Prevent, Hiroshima, Japan
[5] Kurume Univ, Dept Pathol, Sch Med, Fukuoka, Japan
[6] Nayoro City Gen Hosp, Dept Gastroenterol, Nayoro, Japan
[7] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol, Yokohama, Japan
[8] Shin Yurigaoka Gen Hosp, Dept Gastroenterol, Kawasaki, Japan
[9] Iwate Med Univ, Dept Internal Med, Div Hepatol, Yahaba, Japan
[10] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Toon, Japan
[11] Ogaki Municipal Hosp, Dept Clin Res, Ogaki, Japan
[12] Ogaki Municipal Hosp, Dept Gastroenterol & Hepatol, Ogaki, Japan
[13] Saga Univ, Liver Ctr, Saga Med Sch, Saga, Japan
[14] Saga Univ Hosp, Dept Lab Med, Saga, Japan
[15] Tokyo Med Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan
[16] Int Univ Hlth & Welf, Sanno Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan
[17] Kurume Univ Res, Ctr Innovat Canc Therapy, Kurume, Japan
[18] Gifu Kyoritsu Univ, Dept Nursing, Ogaki, Japan
关键词
Attenuation imaging (ATI); Controlled attenuation parameter (CAP); Magnetic resonance imaging-based proton density fat fraction (MRIPDFF); 2-dimensional share wave elastography (2D-SWE); Hepatic steatosis; LIVER-DISEASE; FIBROSIS; STEATOHEPATITIS;
D O I
10.1007/s00535-025-02224-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundAttenuation Imaging (ATI) and controlled attenuation parameter (CAP) are non-invasive ultrasound-based methods for diagnosing hepatic steatosis. However, reports on the clinical usefulness of ATI are limited. We aimed to compare the ability of ATI and CAP to diagnose hepatic steatosis with magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) as the reference standard. MethodsWe performed a prospective multicenter study of 562 patients with chronic liver disease who underwent ATI, CAP, and MRI-PDFF. Patients with skin-to-liver capsule distance (SCD) <= 25 mm underwent CAP with an M probe; those with SCD > 25 mm underwent CAP with an XL probe. MRI-PDFF was used as the reference standard: S0 corresponds to MRI-PDFF < 5.2%, S1 to 5.2% <= MRI-PDFF < 11.3%, S2 to 11.3% <= MRI-PDFF < 17.1%, and S3 to MRI-PDFF >= 17.1%. ResultsThe correlation coefficients for ATI and MRI-PDFF stratified by body mass index (< 30, >= 30 kg/m2), SCD (< 25, >= 25 mm), 2-dimensional share wave elastography (< 1.8 m/s), fibrosis-4 index (<= 2.67), albumin-bilirubin score (< - 2.60) and type IV collagen 7 s (< 5.0 ng/ml) were significantly higher than those for CAP and MRI-PDFF. Areas under the receiver operating characteristics (95% CI) for ATI and CAP were 0.895 (0.869-0.922) and 0.845 (0.809-0.881) for >= S1 steatosis, 0.944 (0.926-0.963) and 0.881(0.852-0.910) for >= S2 steatosis, and 0.928 (95% CI 0.906-0.950) and 0.860 (95% CI 0.829-0.890) for S3 steatosis. ATI had higher diagnostic performance for all hepatic steatosis grades than CAP. ConclusionsATI is a more useful non-invasive method for diagnosing hepatic steatosis than CAP.
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页数:11
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