Efficacy of Fibrin Sealant in Submental Liposuction: A Prospective Randomized Study

Background The incidence rate of submental liposuction has been increasing in recent years. Although this procedure is relatively simple, serious complications, including fatalities, have been reported, primarily owing to intraoperative and postoperative bleeding. Methods To enhance the safety of liposuction, we examined the efficacy of Beriplast (R) P (CSL Behring, Melbourne, Australia), a physiological tissue adhesive fibrin sealant, in reducing postoperative swelling. Swelling was measured using the image analysis software VECTRA (R) (Vectra AI, Inc., CA, USA). Twenty-nine cases of submental liposuction performed from February to August 2024 were analyzed for tissue volume changes immediately postoperatively and at the time of suture removal, comparing those who received the fibrin sealant to those who did not. Results The group using the fibrin sealant had significantly less postoperative swelling compared to the group that did not use the fibrin sealant (p<0.001). Conclusions The fibrin sealant may be used to effectively suppress postoperative swelling, reducing the risk of complications and improving patient satisfaction, thereby enhancing the overall safety and effectiveness of cosmetic surgery.