A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition

被引：0
|
作者：
Teske, Kelly A.
Michaud, Ani
Rothweiler, Elisabeth
Corona, Cesear
Hoffman, Kaitlin Dunn
Wilkinson, Jennifer
Beck, Michael
Vasta, James
Huber, Kilian
Robers, Matthew
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2024年 / 23卷 / 06期
关键词：
D O I：
10.1158/1538-8514.SYNTHLETH24-A005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A005
引用
收藏
页数：2
相关论文
共 33 条
  • [1] A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition
    Michaud, Ani
    Rothweiler, Elisabeth
    Corona, Cesear
    Beck, Michael
    Wilkinson, Jennifer
    Vasta, James
    Huber, Kilian
    Robers, Matthew
    CANCER RESEARCH, 2024, 84 (06)
  • [2] PRMT5 Inhibition Affects RNA Methylation and Is a Potential Therapeutic Target in BPDCN
    Rethnam, Malini
    Tan, Darren Qiancheng
    Tan, Shi Hao
    Ying, Li
    Yang, Henry
    Suda, Toshio
    BLOOD, 2020, 136
  • [3] Inhibition of PRMT5 results in radiosensitization in lung cancer cell lines
    Sharma, Smitha
    Wu, X.
    Smith, P.
    Denko, N.
    Li, C.
    Lai, H.
    Yan, F.
    Shilo, K.
    Chakravarti, A.
    Sif, S.
    Baiocchi, R.
    Otterson, G.
    Xu-Welliver, Meng
    CANCER RESEARCH, 2014, 74 (19)
  • [4] Glioblastoma with PRMT5 gene upregulation is a key target for tumor cell regression
    Kurdi, Maher
    Fadul, Motaz M.
    Addas, Bassam
    Faizo, Eyad
    Bamaga, Ahmed K.
    Alsinani, Taghreed
    Katib, Yousef
    Alkhotani, Alaa
    Fathaddin, Amany A.
    Turkistani, Alaa N.
    Najjar, Ahmed A.
    Baeesa, Saleh
    Toonsi, Fadi A.
    Almansouri, Majid
    Alkhayyat, Shadi
    ONCOLOGIE, 2024, 26 (02) : 239 - 246
  • [5] Selective PRMT5 inhibition suppresses inflammatory T cell responses and autoimmunity.
    Webb, Lindsay M.
    Savardekar, Himanshu
    Jablonski, Kyle A.
    Amici, Stephanie A.
    Panfil, Amanda
    Li, Linsen
    Green, Patrick L.
    Li, Chenglong
    Baiocchi, Robert A.
    Guerau-De-Arellano, Mireia
    JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [6] Protein arginine methyltransferase 5 (PRMT5) inhibition as a therapeutic strategy in B-cell lymphoma
    Barbash, Olena
    Gerhart, Sarah
    Soong, David
    Thompson, Christine
    de Oca, Rocio Montes
    Zhang, Ping
    McHugh, Charles
    Kuplast, Kristy
    Majer, Christina
    Chesworth, Richard
    Smith, Jesse
    Copeland, Robert
    Penebre, Elayne
    Duncan, Kenneth
    Johnson, Neil
    Carpenter, Chris
    Kruger, Ryan
    CANCER RESEARCH, 2015, 75
  • [7] Exploiting PRMT5, a metabolic and epigenetic regulator, as a novel therapeutic target in mantle cell lymphoma
    Yao, Yixin
    Li, Lingzhi
    Zhang, Liang
    Zhang, Shaojun
    Guo, Hui
    Zhang, Hui
    Badillo, Maria
    Chen, Zhihong
    Hartig, Kimberly
    Jain, Preetesh
    Nomie, Krystle
    Wang, Linghua
    Wang, Michael
    CANCER RESEARCH, 2020, 80 (16)
  • [8] A NanoBRET target engagement assay for querying domain selectivity at full-length polymerase theta in live cells
    Edenson, Steven
    Slater, Michael
    Corona, Cesear
    Beck, Michael
    Vasta, James
    Teske, Kelly
    Michaud, Ani
    Robers, Matthew
    CANCER RESEARCH, 2024, 84 (06)
  • [9] Inhibition of PRMT5 Increases Sensitivity to BH3 Mimetics in Aggressive B Cell Malignancies
    Zhu, Fen
    Ryan, Christine E.
    Hackett, Liam R.
    Collins, Mary C.
    Chong, Stephen Jun Fei
    Davids, Matthew S.
    BLOOD, 2022, 140 : 8842 - 8843
  • [10] PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma
    Brown-Burke, Fiona
    Hwang, Inah
    Sloan, Shelby
    Hinterschied, Claire
    Helmig-Mason, Jobeth
    Long, Mackenzie
    Chan, Wing Keung
    Prouty, Alexander
    Chung, Ji-Hyun
    Zhang, Yang
    Singh, Satishkumar
    Youssef, Youssef
    Bhagwat, Neha
    Chen, Zhengming
    Chen-Kiang, Selina
    Di Liberto, Maurizio
    Elemento, Olivier
    Sehgal, Lalit
    Alinari, Lapo
    Vaddi, Kris
    Scherle, Peggy
    Lapalombella, Rosa
    Paik, Jihye
    Baiocchi, Robert A.
    BLOOD ADVANCES, 2023, 7 (20) : 6211 - 6224
1234