Design, synthesis and biological evaluation of alginate oligosaccharide derivatives

被引：0
|
作者：
Guo, Wenkang [1 ,3 ,4 ,5 ]
Chen, Manchun [2 ]
Zou, Changjie [5 ]
Liu, Weizhi [6 ]
Wang, Weidong [2 ]
Gao, Heyong [5 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Hefei 230000, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou 510080, Peoples R China
[3] Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
[4] Yangtze Delta Pharmaceut Coll, Nantong 226133, Peoples R China
[5] Haitang Jiangsu Biotechnol Co Ltd, Nantong 226133, Peoples R China
[6] Ocean Univ China, Coll Marine Life Sci, Fang Zongxi Ctr, MoE Key Lab Marine Genet & Breeding, Qingdao 266003, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2025年 / 116卷
关键词：
Alginate oligosaccharide; Alginate oligosaccharide derivatives; Acute kidney injury; INJURY;
D O I：
10.1016/j.bmcl.2024.130039
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To discover new potential drug for acute kidney injury (AKI), a series of novel alginate oligosaccharide derivatives were synthesized and characterized by the spectroscopic analysis. By using the controlled experimental method, the target compounds were evaluated preliminarily for therapeutic activity in AKI. The results demonstrated that compounds 2a, 2b, 2c and 3b exhibited notable inhibitory activity against the expression of related proteins at 250 mu g/ml in vitro. Furthermore, the in vivo activity of 2a and 2b was found to be comparable to that of the trisaccharide (AOSC).
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页数：3
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