Efficacy of complete versus culprit-lesion only revascularization in patients with diabetes undergoing percutaneous coronary intervention: a pilot meta-analysis

Diabetes is a strong independent predictor of unfavorable cardiovascular outcomes in patients with coronary artery disease, and diabetic patients have a higher prevalence of multivessel disease. The impact of diabetes status on outcomes in patients undergoing complete versus culprit-only revascularization during percutaneous coronary intervention remains unexplored. A comprehensive literature search was conducted using MEDLINE, EMBASE, and SCOPUS. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model in Review Manager (version 5.4), with a P-value of <0.05 considered significant. Five studies comprising a total of 4686 patients met our inclusion criteria. No statistically significant differences were observed between the two groups in terms of all-cause mortality (RR: 0.79; 95% CI: 0.56-1.12; P = 0.19; I-2 = 66%), cardiovascular-related death (RR: 1.12; 95% CI: 0.74-1.69; P = 0.60; I-2 = 29%), myocardial infarction (RR: 0.78; 95% CI: 0.57-1.08; P = 0.13; I-2 = 12%), and stroke (RR: 1.06; 95% CI: 0.52-2.16; P = 0.88; I-2 = 0%).