Using different zebrafish models to explore liver regeneration

被引:0
|
作者
Mo, Dashuang [1 ]
Lv, Mengzhu [1 ]
Mao, Xiaoyu [2 ]
机构
[1] Guizhou Med Univ, Coll Basic Med Sci, Dept Immunol, Guiyang, Guizhou, Peoples R China
[2] Sichuan Int Studies Univ, Coll Language Intelligence, Chongqing, Peoples R China
基金
中国国家自然科学基金;
关键词
zebrafish; liver injury; biliary epithelial cell; hepatocyte; regeneration; TOPOISOMERASE-II-ALPHA; STEM-CELL PROLIFERATION; TROUT SALMO-GAIRDNERI; PARTIAL-HEPATECTOMY; RICHARDSON LIVER; FUNCTIONAL UNITS; BINDING-PROTEIN; DNA-SYNTHESIS; KINASE; HOMEOSTASIS;
D O I
10.3389/fcell.2024.1485773
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The liver possesses an impressive capability to regenerate following various injuries. Given its profound implications for the treatment of liver diseases, which afflict millions globally, liver regeneration stands as a pivotal area of digestive organ research. Zebrafish (Danio rerio) has emerged as an ideal model organism in regenerative medicine, attributed to their remarkable ability to regenerate tissues and organs, including the liver. Many fantastic studies have been performed to explore the process of liver regeneration using zebrafish, especially the extreme hepatocyte injury model. Biliary-mediated liver regeneration was first discovered in the zebrafish model and then validated in mammalian models and human patients. Considering the notable expansion of biliary epithelial cells in many end-stage liver diseases, the promotion of biliary-mediated liver regeneration might be another way to treat these refractory liver diseases. To date, a comprehensive review discussing the current advancements in zebrafish liver regeneration models is lacking. Therefore, this review aims to investigate the utility of different zebrafish models in exploring liver regeneration, highlighting the genetic and cellular insights gained and discussing the potential translational impact on human health.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Using zebrafish mutant models to explore the genetic basis of craniofacial variation in evolution
    Hawkins, M. Brent
    Albertson, R. Craig
    Harris, Matthew
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2014, 164 (08) : 1880 - 1881
  • [2] Different physiology of interferon-α/-γ in models of liver regeneration in the rat
    Batusic, Danko S.
    von Bargen, Alexander
    Blaschke, Sabine
    Dudas, Jozsef
    Ramadori, Giuliano
    HISTOCHEMISTRY AND CELL BIOLOGY, 2011, 136 (02) : 131 - 144
  • [3] Different physiology of interferon-α/-γ in models of liver regeneration in the rat
    Danko S. Batusic
    Alexander von Bargen
    Sabine Blaschke
    Jozsef Dudas
    Giuliano Ramadori
    Histochemistry and Cell Biology, 2011, 136 : 131 - 144
  • [4] Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging
    Kishi, Shuji
    TRANSLATIONAL RESEARCH, 2014, 163 (02) : 123 - 135
  • [5] Macrophages in Zebrafish Models of Liver Diseases
    Shwartz, Arkadi
    Goessling, Wolfram
    Yin, Chunyue
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [6] Animal models of liver regeneration
    Palmes, D
    Spiegel, HU
    BIOMATERIALS, 2004, 25 (09) : 1601 - 1611
  • [7] Genetically engineered zebrafish as models of skeletal development and regeneration
    Henke, Katrin
    Farmer, D'Juan T.
    Niu, Xubo
    Kraus, Jessica M.
    Galloway, Jenna L.
    Youngstrom, Daniel W.
    BONE, 2023, 167
  • [8] Examining Muscle Regeneration in Zebrafish Models of Muscle Disease
    Montandon, Margo
    Currie, Peter D.
    Ruparelia, Avnika A.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, (167): : 1 - 12
  • [9] Delineating the roles of neutrophils and macrophages in zebrafish regeneration models
    Keightley, Maria-Cristina
    Wang, Chieh-Huei
    Pazhakh, Vahid
    Lieschke, Graham J.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2014, 56 : 92 - 106
  • [10] Heart and liver regeneration in zebrafish using silver nanoparticle synthesized from Turbinaria conoides - In vivo
    Ali, M. Syed
    Anuradha, V.
    Yogananth, N.
    Krishnakumar, S.
    BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, 2019, 17 : 104 - 109