Efficacy of N-Acetylcysteine as an Adjuvant Therapy for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

被引：0

作者：

He, Tingting ^{[1
]}

Ren, Kehui ^{[1
]}

Xiang, Li ^{[1
]}

Yao, Huan ^{[2
]}

Huang, Yucheng ^{[1
]}

Gao, Yongxiang ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu, Sichuan, Peoples R China

[2] Sichuan Prov Engn Res Ctr Innovat Redev Famous Cla, Pengzhou, Sichuan, Peoples R China

来源：

BRITISH JOURNAL OF HOSPITAL MEDICINE | 2024年 / 85卷 / 11期

基金：

中国国家自然科学基金;

关键词：

N-acetylcysteine; rheumatoid arthritis; oxidative stress; inflammation; meta-analysis;

D O I：

10.12968/hmed.2024.0560

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/Background Rheumatoid arthritis (RA) is an inflammatory autoimmune disease and N-acetylcysteine (NAC) is considered a potential therapeutic agent for RA due to strong antioxidant and antiinflammatory properties. Therefore, this systematic review and meta-analysis aimed to evaluate the efficacy of NAC as an adjuvant therapy for RA. Methods A systematic search was conducted across five databases from inception to 1 August 2024, including CINAHL, Cochrane Library, EMBASE, PubMed, and Web of Science. The Cochrane riskof-bias tool for randomized trials was used to assess the quality of the included studies. Sensitivity analysis was performed when significant heterogeneity was identified. Results Four studies involving 204 patients were included in our meta-analysis. The results indicated that NAC alleviated disease activity in RA patients (Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR): mean difference (MD) = 0.54). Additionally, NAC reduced inflammatory markers (erythrocyte sedimentation rate (ESR): MD = 3.00). However, the beneficial effects of NAC on oxidative stress in RA patients were not observed. Conclusion This meta-analysis demonstrated the efficacy of NAC in reducing inflammatory markers, improving joint tenderness, and swelling in patients with RA.

引用

页数：16