Graft-versus-host disease variety toxic epidermal necrolysis. Case report

被引：0

作者：

Zuniga-Lara, Elsa M. ^{[1
]}

Zambrano-Virgen, Cesar M. ^{[1
]}

Gaytan-Morales, Jose F. ^{[2
]}

Mendoza-Camargo, Fredenet O. ^{[2
]}

Gomez-Dominguez, Yazmin A. ^{[2
]}

机构：

[1] Inst Nacl Salud, Hosp Infantil Mexico Federico Gomez, Serv Pediat, Mexico City, Mexico

[2] Hosp Infantil Mexico Dr Federico Gomez, Serv Trasplante Celulas Progenitoras Hematopoyet, Mexico City, Mexico

来源：

BOLETIN MEDICO DEL HOSPITAL INFANTIL DE MEXICO | 2024年 / 81卷 / 06期

关键词：

Toxic epidermal necrolysis; Graft-versus-host disease; Hematopoietic stem cell transplantation;

D O I：

10.24875/BMHIM.24000048

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN). Clinical case: An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD. Conclusion: The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.

引用

页码：368 / 371

页数：4

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