Comparative Efficacy of Non-contrast vs. Contrast-enhanced CT Radiomics in Predicting Coronary Artery Plaques Among Patients with Low Agatston Scores

Rationale and Objectives: Patients with a low Agatston score often present with clinical signs and symptoms suggestive of coronary artery disease, despite having minimal calcium deposits. This study aimed to compare the efficacy of low-dose non-contrast cardiac CT with coronary computed tomography angiography (CCTA) in pericoronary adipose tissue (PCAT) radiomics for predicting coronary artery plaques, using CCTA as the reference standard. Materials and Methods: This retrospective study analyzed 459 patients with suspected coronary artery disease and a coronary artery calcium score < 100 Agatston units, who were treated between June 2021 and December 2023 at a tertiary hospital. Three predictive models for coronary artery plaques were developed: (1) a clinical factor model, (2) a hybrid model integrating clinical factors and CT PCAT radiomics, and (3) a hybrid model integrating clinical factors and CCTA PCAT radiomics. Multivariable logistic regression and receiver operating characteristic curve evaluations were performed to develop and validate predictive models. Results: Both hybrid models showed significant correlations in the training set (r = 0.890, P < 0.001) and the validation set (r = 0.920, P < 0.001). The mean agreement in the training set is 0, with 3.42% (11/322) of the data points outside the 95% CI (-0.18-0.18, P < 0.001). The mean agreement in the validation set is -0.244, with 6.57% (9/137) of the data points outside the 95% CI (-0.443-0.045, P < 0.001). Conclusions: Non-contract CT PCAT radiomics showed comparable efficacy to CCTA PCAT radiomics in predicting coronary artery plaques among patients with low Agatston scores. (c) 2024 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.