Viral Loads of Pneumoviruses: Correlation With Coinfection Rates and Disease Severity

被引：0

作者：

Talah, Sarah ^{[1
,2
]}

Carbonneau, Julie ^{[1
,2
,3
]}

Hamelin, Marie-Eve ^{[1
,2
,3
]}

Gilca, Rodica ^{[1
,2
,4
]}

Boivin, Guy ^{[1
,2
,3
]}

机构：

[1] CHU Quebec, Res Ctr Infect Dis, Quebec City, PQ, Canada

[2] Laval Univ, Quebec City, PQ, Canada

[3] Int Lab Resp Viruses RespiVir Canada France, Quebec City, PQ, Canada

[4] Quebec Publ Hlth Inst, Quebec City, PQ, Canada

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 11期

基金：

加拿大健康研究院;

关键词：

coinfection; HMPV; interference; RSV; severity; viral load; HUMAN METAPNEUMOVIRUS; INFECTIONS; INFLUENZA; VIRUS;

D O I：

10.1002/jmv.70054

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We looked at the interactions between viral loads, coinfection rates and disease severity for children infected with two pneumoviruses: human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The HMPV RNA load in nasopharyngeal swabs of hospitalized children was significantly higher in mono-infections compared to coinfections but this was not the case for RSV, which could be explained by different innate immune responses. Also, the viral load of neither of the two viruses was associated with disease severity although RSV-infected children had higher severity scores than HMPV-infected children.

引用

页数：3

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