c-Met protein overexpression and telisotuzumab vedotin efficacy by biopsy age, type, and region in the LUMINOSITY phase II study

被引:0
|
作者
Bar, J. [1 ]
Baijal, S. [2 ]
Luo, A. [3 ]
Zhang, N. [4 ]
Ratajczak, C. [5 ]
Ansell, P. J. [6 ]
Lu, S. [7 ]
Camidge, D. R. [8 ]
机构
[1] Univ Hosp Birmingham, Sheba Med Ctr, Jusidman Canc Ctr, Ramat Gan, Israel
[2] NHS Fdn Trust, Med Oncol Dept, Birmingham, W Midlands, England
[3] AbbVie Inc, Oncol Stat, Chicago, IL USA
[4] AbbVie Inc, CDx Strategy & Precis Med, Chicago, IL USA
[5] AbbVie Inc, Oncol Early Dev, Chicago, IL USA
[6] AbbVie Inc, Precis Med Oncol, Chicago, IL USA
[7] Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Shanghai, Peoples R China
[8] Univ Colorado, Med Oncol, Ctr Canc, Aurora, CO USA
关键词
D O I
10.1016/j.annonc.2024.08.1434
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1379P
引用
收藏
页码:S866 / S866
页数:1
相关论文
共 50 条
  • [31] A phase II study of the c-Met RTK inhibitor XL880 in patients (pts) with papillary renal-cell carcinoma (PRC)
    Ross, R. W.
    Stein, M.
    Sarantopoulos, J.
    Eisenberg, P.
    Logan, T.
    Srinivas, S.
    Rosenberg, J.
    Vaishampayan, U.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [32] Identification of a 7H-pyrrolo[2,3-d]pyrimidin derivatives as selective type II c-Met/Axl inhibitors with potent antitumor efficacy
    Qin, Songhui
    Xie, Lixin
    Tang, Minghai
    Ni, Hengfan
    Yang, Tao
    BIOORGANIC CHEMISTRY, 2025, 156
  • [33] Phase I/II study of 549076, a multi-target inhibitor of c-MET, AXL, FGFR in combination with bevacizumab in patients with recurrent glioblastoma.
    Hoang-Xuan, Khe
    Hottinger, Andreas
    Royer-Perron, Louis
    Alentorn, Agusti
    Savatovsky, Julien
    De Micheli, Rita
    Homicsko, Krisztian
    Banquet, Sebastien
    Pauly, Jeanne
    Sudey, Isabelle
    Tell, Roger
    Therasse, Patrick
    Barrie, Maryline
    Campello, Chantal
    Chinot, Olivier L.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [34] A Phase II Study of the c-Met Inhibitor Tivantinib in Combination with FOLFOX for the Treatment of Patients with Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction, or Stomach
    Pant, Shubham
    Patel, Manish
    Kurkjian, Carla
    Hemphill, Brian
    Flores, Maria
    Thompson, Dana
    Bendell, Johanna
    CANCER INVESTIGATION, 2017, 35 (07) : 463 - 472
  • [35] Phase II clinical study evaluating the efficacy and safety of disitamab vedotin combined with sintilimab and S-1 in the conversion treatment of HER2-overexpression unresectable gastric cancer.
    Liang, Han
    Wang, Xiaona
    Shang, Liang
    Chen, Xiaodong
    Cheng, Xiangdong
    Li, Ziyu
    Wei, Bo
    Zheng, Zhichao
    Li, Guoxin
    Ji, Gang
    Zhang, Zizhen
    Tian, Yantao
    Zhao, Qun
    Yang, Lin
    Liu, Heli
    Chen, Hao
    Liu, Yanliang
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : TPS428 - TPS428
  • [36] Vebreltinib for Advanced Non-Small Cell Lung Cancer Harboring c-Met Exon 14 Skipping Mutation: A Multicenter, Single-Arm, Phase II KUNPENG Study
    Yang, Jin-Ji
    Zhang, Yan
    Wu, Lin
    Hu, Jie
    Wang, Zhe-Hai
    Chen, Jing-Hua
    Fan, Yun
    Lin, Gen
    Wang, Qi-Ming
    Yao, Yu
    Zhao, Jun
    Chen, Yuan
    Fang, Jian
    Song, Yong
    Zhang, Wei
    Cheng, Ying
    Guo, Ren-Hua
    Li, Xing-Ya
    Shi, He-Peng
    Xue, Wei-Zhe
    Han, Di
    Zhang, Pei-Long
    Wu, Yi-Long
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (31)
  • [37] Using modelling & simulation to integrate mouse PK-PD-efficacy with preliminary human PK data to inform the Phase II doses and schedule for the experimental c-Met inhibitor AZD6094 (Volitinib)
    Jones, R.
    Cheung, A.
    Coleman, T.
    Ballard, P.
    D'Cruz, C.
    Schuller, A.
    Frigault, M.
    Gu, Y.
    Sai, Y.
    Weiguo, S.
    Ren, Y.
    Qing, W.
    Lindbom, L.
    Petersson, K.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 125 - 126
  • [38] Phase II Study of Tivantinib and Cetuximab in Patients With KRAS Wild-type Metastatic Colorectal Cancer With Acquired Resistance to EGFR Inhibitors and Emergence of MET Overexpression: Lesson Learned for Future Trials With EGFR/MET Dual Inhibition
    Rimassa, Lorenza
    Bozzarelli, Silvia
    Pietrantonio, Filippo
    Cordio, Stefano
    Lonardi, Sara
    Toppo, Laura
    Zaniboni, Alberto
    Bordonaro, Roberto
    Di Bartolomeo, Maria
    Tomasello, Gianluca
    Dadduzio, Vincenzo
    Tronconi, Maria Chiara
    Piombo, Chiara
    Giordano, Laura
    Gloghini, Annunziata
    Di Tommaso, Luca
    Santoro, Armando
    CLINICAL COLORECTAL CANCER, 2019, 18 (02) : 125 - +
  • [39] A phase II study of the c-Met inhibitor tivantinib (tiv) in combination with FOLFOX for the treatment of patients (pts) with previously untreated metastatic adenocarcinoma of the distal esophagus, gastroesophageal (GE) junction, or stomach.
    Pant, Shubham
    Patel, Manish R.
    Kurkjian, Carla
    Hemphill, Michael Brian
    Flores, Maria Regina C.
    Thompson, Dana Shelton
    Bendell, Johanna C.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [40] Phase II study of ABBV-399 (Process II) in patients with C-MET positive stage IV/recurrent lung squamous cell cancer (SCC): LUNG-MAP sub-study S1400K (NCT03574753).
    Waqar, Saiama Naheed
    Redman, Mary Weber
    Arnold, Susanne M.
    Hirsch, Fred R.
    Mack, Philip C.
    Schwartz, Lawrence Howard
    Gandara, David R.
    Stinchcombe, Tom
    Leighl, Natasha B.
    Ramalingam, Suresh S.
    Tanna, Saloni H.
    Raddin, Ryan S.
    Minichiello, Katherine
    Kelly, Karen
    Bradley, Jeffrey D.
    Herbst, Roy S.
    Papadimitrakopoulou, Vassiliki
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)