There is a long and complex history of Christian-Muslim engagement, one which is fraught by socio-political tensions and complicated by fear. Theological tensions likewise contribute to the sibling rivalry between these Abrahamic faiths. Accounting for fundamental theological differences between Islam and Christianity, and noting a potential dichotomy between apologetic-style and interfaith engagement, this article contends that effective Christian-Muslim relations must navigate both opposing truth claims and efforts to seek peace. Consequently, comparative theology is critically evaluated, from an evangelical Christian perspective, as a potential mediating approach. In considering the complex relationship between comparative theology and theology of religion, and indeed, between theology and 'people of faith', recommendations are formulated with a view to contributing to effective Christian-Muslim relations. The overall aim of this research therefore is to explore approaches to developing more effective Christian-Muslim relations, with a specific focus on comparative theology. While motivated by and accounting for a personal Christian-Muslim sibling relationship, the research method predominantly references academic literature, with sections structured by an amended version of Osmer's four-task model of practical theology. Findings from this research discern that comparative theology is not quite the mediating approach sought; however, its potential contribution towards a 'hybrid approach' is explored. The implications of this article seek to encourage orthodox Muslims and evangelical Christians to engage in comparative exchanges that employ a balanced and in-depth approach to understanding our respective faiths. Finally, this article emerges from within the UK; therefore, discussions presented may be differently received by evangelical Christians operating out of divergent biographical contexts.