Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response

被引：0

作者：

Marie-Christin Schulz ^{[1
]}

Nathalie Wolff ^{[1
]}

Michael Kopf ^{[1
]}

Micheal Gekle ^{[1
]}

机构：

[1] Universität Halle- Wittenberg,Julius

来源：

Cell Communication and Signaling | / 23卷 / 1期

关键词：

Cellular crosstalk; Chronic kidney diseases; Local interstitial acidosis; Local inflammation; IL-6 effects; p38-signaling;

D O I：

10.1186/s12964-025-02180-5

中图分类号：

学科分类号：

摘要：

引用

共 21 条

[1] Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling
Marie-Christin Schulz
Michael Kopf
Michael Gekle
Cell Communication and Signaling, 22
[2] Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling
Schulz, Marie-Christin
Kopf, Michael
Gekle, Michael
CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
[3] Acidosis-induced inflammatory response in tubule cells and fibroblasts is amplified by tubule-fibroblast crosstalk and mediated via p38 signaling
Schulz, Marie-Christin
Wolff, Nathalie
Kopf, Michael
Gekle, Michael
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2024, 39
[4] Acidosis-induced inflammatory response in tubule cells and fibroblasts is amplified by tubule-fibroblast crosstalk and mediated via p38 signaling
Schulz, Marie-Christin
Wolff, Nathalie
Kopf, Michael
Gekle, Michael
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2024, 39 : I1926 - I1927
[5] Interleukin-1β-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK
Zhang, M
Tang, JW
Li, XM
NEPHRON EXPERIMENTAL NEPHROLOGY, 2005, 99 (03): : 68 - 76
[6] Interleukin-10 induced transdifferentiation of renal proximal tubular cells is mediated by p38 MAPK activation.
Zhang, M
Li, XM
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 : 287A - 287A
[7] N-acetylcysteine attenuates TNF-α-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells
Hashimoto, S
Gon, Y
Matsumoto, K
Takeshita, I
Horie, T
BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132 (01) : 270 - 276
[8] Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcεRI-mediated activation:: involvement of p38 MAPK
Boudreau, RTM
Hoskin, DW
Lin, TJ
JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (05) : 1075 - 1081
[9] SDF-1β Protects Palmitate-Induced Fibrotic Response in Cardiac Cells via Activation of AMPK and p38 MAPK-Mediated IL-6 Excretion
Zhao, Yuguang
Dai, Junying
Wang, Guanjun
Cai, Lu
Li, Wei
DIABETES, 2012, 61 : A294 - A294
[10] OXALATE INDUCED P38 MITOGEN ACTIVATED PROTEIN KINASE ACTIVATION IS MEDIATED BY MITOGEN ACTIVATED PROTEIN KINASE KINASE-6 (MKK6) IN HK-2 CELLS, A LINE OF HUMAN KIDNEY EPITHELIAL CELLS
Koul, Sweaty
Maroni, Paul
Meacham, Randall B.
Koul, Hari
JOURNAL OF UROLOGY, 2010, 183 (04): : E763 - E763

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