Pd-Catalyzed Allylic Substitution Using Nucleophilic Amines: Access to Functionalized Mono- and Bis-N-Allyl Synthons

被引：0
|
作者：
Gao, Fengyun [1 ,2 ]
Ghorai, Debasish [1 ]
Benet-Buchholz, Jordi [1 ]
Kleij, Arjan W. [1 ,3 ]
机构：
[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain
[2] Univ Rovira I Virgili, Dept Quim Fis & Inorgan, 43007 Tarragona, Spain
[3] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co 23, Barcelona 08010, Spain
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 22期
关键词：
Allylic Substitution; Homogeneous Catalysis; Nucleophilic Amines; Palladium; Synthetic Chemistry; KINETIC ASYMMETRIC TRANSFORMATIONS; VINYLETHYLENE CARBONATES; ENANTIOSELECTIVE CONSTRUCTION; ALLENYLETHYLENE CARBONATES; PD-2(DBA)(3); ANNULATION; REACTIVITY; SCAFFOLDS; ALKENES; WATER;
D O I：
10.1002/adsc.202400685
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We here report a catalytic strategy to enable the decarboxylative allylic amination of vinyl cyclic carbonates using various aliphatic and nucleophilic amines. The use of a protic medium and chelating diphosphine ligands are the main drivers towards chemoselective allylic amine formation, thereby minimizing undesired ligand-driven complex speciation and aminolysis of the involved substrate. This improved approach amplifies the repertoire of allylic amine synthons that can be prepared from a variety of substrate combinations.
引用
收藏
页码：4709 / 4714
页数：6
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