Aspirin in Cancer Therapy: Pharmacology and Nanotechnology Advances

被引:0
|
作者
Laila, Umm E. [1 ]
Zhao, Zi Lon [1 ]
Liu, Huai [1 ]
Xu, Zhi-Xiang [1 ]
机构
[1] Henan Univ, Sch Life Sci, Kaifeng 475001, Henan, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2025年 / 20卷
基金
中国国家自然科学基金;
关键词
aspirin; cancer therapy; signaling pathways; nanotechnology; targeted drug delivery; NF-KAPPA-B; LOW-DOSE ASPIRIN; HEPATOCELLULAR-CARCINOMA CELLS; SULFIDE-RELEASING HYBRID; ENGINEERED MOUSE MODEL; COLORECTAL-CANCER; COLON-CANCER; BREAST-CANCER; IN-VITRO; SIGNALING PATHWAY;
D O I
10.2147/IJN.S505636
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has garnered significant attention for its anti-cancer potential. This review explores the pharmacological properties, chemical dynamics, and evolving therapeutic applications of aspirin, with an emphasis on its integration into advanced cancer therapies. Aspirin demonstrates broad-spectrum efficacy across diverse cancer types by modulating signaling pathways such as COX-dependent and COX-independent mechanisms, including Wnt, NF-kappa B, beta-catenin/ TCF, and IL-6/STAT3. Recent advancements highlight the role of nanotechnology in enhancing aspirin's targeted delivery, therapeutic effectiveness, and patient outcomes. Nanoparticle-based formulations, including liposomes, solid lipid nanoparticles, and mesoporous silica nanoparticles, offer improved solubility, stability, and bioavailability, enabling controlled drug release and tumor-specific targeting. These innovations reduce systemic toxicity and enhance therapeutic effects, paving the way for aspirin's integration into personalized cancer treatments. Ongoing clinical studies reinforce its safety profile, underscoring aspirin's role in cancer pharmacotherapy. This review calls for continued research into aspirin's repurposing in combination therapies and novel delivery systems to maximize its therapeutic potential.
引用
收藏
页码:2327 / 2365
页数:39
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