Functionalization of Biomimetic Polydopamine Shells Constructed onto Bismuth-Core Particles for pH-Mediated Drug Targeting to Heal Bacterial Infections

被引：0

作者：

Rahman, Md. Abdur ^{[1
]}

Akter, Pinky ^{[1
]}

Habib, Md. Rowshanul ^{[2
]}

Rahman, Md. Ataur ^{[1
]}

Mahiuddin, Md. ^{[3
]}

Rahman, Md. Mahbubor ^{[1
]}

Islam, Md. Shahidul ^{[1
]}

Miah, M. A. Jalil ^{[1
]}

Ahmad, Hasan ^{[1
]}

机构：

[1] Univ Rajshahi, Fac Sci, Dept Chem, Polymer Colloids & Nanomat Res Lab, Rajshahi 6205, Bangladesh

[2] Rajshahi Univ, Fac Sci, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh

[3] Univ Khulna, Chem Discipline, Khulna 9208, Bangladesh

来源：

BIOCONJUGATE CHEMISTRY | 2025年 / 36卷 / 03期

关键词：

OXIDE NANOPARTICLES; FACILE SYNTHESIS; DOPAMINE; SURFACE; POLYMERIZATION; COMPATIBILITY;

D O I：

10.1021/acs.bioconjchem.5c00003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonhealing chronic bacterial infections are very challenging to both patients and the healthcare-providing system. Multimodal therapy enhances the antibiotic efficacy to treat infections via combating multidrug resistance through cumulative therapeutic effects. Functionalized polydopamine (PDA)-coated Bi particles having a core-shell structure may treat such chronic infections. We fabricated a new advanced material based on Tris-functionalized PDA and Bi using a facile three-step protocol for healing drug-resistant bacterial infections. The fabrication of Bi particles, PDA coating on Bi particles, and their Tris functionalization were confirmed by X-ray diffraction, and spectroscopic and thermogravimetric analyses. Tris-functionalized PDA-coated Bi particles, abbreviated as Bi/PDA-Tris, exhibited a higher average diameter, improved hydrophilicity, aqueous dispersity, and colloidal stability. Bi/PDA-Tris showed a delicate surface morphology, narrow size distribution, spherical shape, and core-shell structure. In vitro bovine serum albumin and hemolysis assays showed minimal protein adsorption and the desirable hemocompatibility of Bi/PDA-Tris. Antibacterial gentamicin (GM)-immobilized Bi/PDA-Tris showed pH-mediated sustained drug release kinetics under acidic conditions. The in vitro study of GM-loaded Bi/PDA-Tris particles exhibited significant bacterial growth inhibition and bactericidal activity. Tris functionalization effectively enhances the antibacterial efficacy of the PDA shell under acidic conditions to target and heal bacterial infections. This approach has introduced economic, nontoxic, easy-to-use, relatively more biocompatible Bi particles as a substituent for precise metals like Pt, Au, and Ag for the development of core-shell composite materials.

引用

页码：563 / 577

页数：15