The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity

被引：2

作者：

Mindt, Monica Rivera ^{[1
,2
,3
,4
,5
]}

Arentoft, Alyssa ^{[6
]}

Calcetas, Amanda T. ^{[1
]}

Guzman, Vanessa A. ^{[5
]}

Amaza, Hannatu ^{[7
]}

Ajayi, Adeyinka ^{[5
]}

Ashford, Miriam T. ^{[8
,9
]}

Ayo, Omobolanle ^{[5
]}

Barnes, Lisa L. ^{[10
,11
]}

Camuy, Alicia ^{[5
]}

Conti, Catherine ^{[8
,9
]}

Diaz, Adam ^{[8
,9
]}

Easter, Bashir ^{[11
,12
]}

Gonzalez, David J. ^{[11
]}

Dotson, Yolanda Graham ^{[11
,13
]}

Hoang, Isabella ^{[7
]}

Germano, Kaori Kubo ^{[1
]}

Maestre, Gladys E. ^{[11
,14
]}

Magana, Fabiola ^{[7
]}

Meyer, Oanh L. ^{[11
,15
]}

Miller, Melanie J. ^{[8
,9
]}

Nosheny, Rachel ^{[8
,9
,16
,17
]}

Park, Van M. Ta ^{[11
,18
,19
]}

Parkins, Shaniya ^{[5
]}

Thomas, Lisa Renier ^{[7
]}

Strong, Joe ^{[7
]}

Talavera, Sandra ^{[1
,5
,11
]}

Verney, Steven P. ^{[11
,20
]}

Weisensel, Trinity ^{[7
]}

Weiner, Michael W. ^{[8
,9
,16
,17
]}

Okonkwo, Ozioma C. ^{[7
]}

机构：

[1] Fordham Univ, Dept Psychol, Bronx, NY USA

[2] Fordham Univ, Dept Latin Amer, Bronx, NY USA

[3] Fordham Univ, Latino Studies Inst, Bronx, NY USA

[4] Fordham Univ, Dept African & African Amer Studies, Bronx, NY USA

[5] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY USA

[6] Calif State Univ, Dept Psychol, Northridge, CA USA

[7] Univ Wisconsin Madison, Wisconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[8] Northern Calif Inst Res & Educ NCIRE, San Francisco, CA USA

[9] VA Adv Imaging Res Ctr, Vet Affairs Med Ctr, San Francisco, CA USA

[10] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL USA

[11] Alzheimers Dis Neuroimaging Initiat, Community Sci Partnership Board CSPB, New York, NY USA

[12] Melanin Minded LLC, Milwaukee, WI USA

[13] Indiana Univ Sch Med, Indiana Alzheimers Dis Res Ctr, Indianapolis, IN USA

[14] Univ Texas Rio Grande Valley, Dept Neurosci, Sch Med, Rancho Viejo, TX USA

[15] Univ Calif Davis, Sch Med, Dept Neurol, Sacramento, CA USA

[16] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA USA

[17] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[18] Univ Calif San Francisco, Sch Nursing, Dept Community Hlth Syst, San Francisco, CA USA

[19] Univ Calif San Francisco, Asian Amer Res Ctr Hlth ARCH, San Francisco, CA USA

[20] Univ New Mexico, Dept Psychol, Albuquerque, NM USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 12期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Alzheimer's disease; cognitive aging; community-engaged research; cultural humility; dementia; diversity; external validity; generalizability; health disparities; health equity; inclusion science; inclusive participation; underrepresented populations; SACRAMENTO AREA LATINO; AFRICAN-AMERICANS; COGNITIVE IMPAIRMENT; OLDER-ADULTS; RECRUITMENT; PERFORMANCE; DEMENTIA; REGISTRY; PARTICIPATION; ASSOCIATIONS;

D O I：

10.1002/alz.14242

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment. METHODS: URPs include ethnoculturally minoritized, lower education (<= 12 years), and rural populations. The CI-CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community-Science Partnership Board). RESULTS: As of April 2024, 60% of ADNI-4 new in-clinic enrollees were from ethnoculturally or educationally URPs. This exceeds ADNI-4's >= 50% URP representation goal for new enrollees but may not represent final enrollment. DISCUSSION: Findings show a CI-CER model increases URP enrollment in AD/ADRD clinical research and has important implications for clinical trials to advance health equity.

引用

页码：8279 / 8293

页数：15

共 1 条

[1] Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4
Weiner, Michael W.
Veitch, Dallas P.
Miller, Melanie J.
Aisen, Paul S.
Albala, Bruce
Beckett, Laurel A.
Green, Robert C.
Harvey, Danielle
Jack, Clifford R., Jr.
Jagust, William
Landau, Susan M.
Morris, John C.
Nosheny, Rachel
Okonkwo, Ozioma C.
Perrin, Richard J.
Petersen, Ronald C.
Rivera-Mindt, Monica
Saykin, Andrew J.
Shaw, Leslie M.
Toga, Arthur W.
Tosun, Duygu
Trojanowski, John Q.
ALZHEIMERS & DEMENTIA, 2023, 19 (01) : 307 - 317

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