Perfusion MRI in Cerebral Venous and Sinus Thrombosis

Background and Purpose: Cerebral venous and sinus thrombosis (CVST) leads to perfusion abnormality in the brain. Our aim was to assess perfusion abnormalities in the center and periphery of the parenchymal lesion in CVST patients and correlate with the clinical outcome. Materials and Methods: Dynamic susceptibility contrast (DSC) perfusion imaging was performed in patients with CVST. Relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and mean transit time (MTT) values were obtained in the center and periphery of the parenchymal lesion. Results: A total of 30 consecutive patients of CVST were included in the study. Parenchymal lesion was present in 21 (70%) patients. In rest 9, perfusion map was showing some abnormality although conventional MRI was normal. Mean rCBV and MTT were increasing from periphery of the lesion to the center (rCBV 69.93 29.79 at periphery (PL2) to 92.49 +/- 32.07 at center of the lesion and 69.19 +/- 25.52 at normal appearing contralateral brain parenchyma (NABP). MTT 11.83 +/- 3.76 at periphery (PL2) to 15.27 +/- 5.49 at center of the lesion and 10.63 +/- 3.37 at NABP). rCBV and MTT from abnormal perfusion areas from 9 patients without parenchymal abnormalities are 92.89 +/- 17.76 and 15.92 +/- 3.66 respectively. Conclusion: There is an increasing trend of MTT and rCBV from periphery to center of the parenchymal lesion. MTT is the most consistent parameter to be abnormal in patients of CVST even in patients without parenchymal lesion. Residual neurological deficit was found in patients with increased rCBV and having large hemorrhagic infarct.