Neoplastic small extracellular vesicles cause DNA damage and inhibit DNA damage repair in Barrett's esophagus cells: A model for synthetic lethality by PARP inhibitors

被引：0

作者：

Zhang, Q. ^{[1
]}

Dunbar, K. ^{[2
]}

Dixon, D. ^{[3
]}

Spechler, S. ^{[4
]}

Souza, R. ^{[4
]}

Bansal, A. ^{[5
,6
]}

机构：

[1] Baylor Scott & White Res Inst, Ctr Esophageal Res, Dallas, TX USA

[2] VA North Texas Hlth Care Syst, Dept Internal Med, Dallas, TX USA

[3] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

[4] Baylor Univ, Med Ctr, Dept Med, Ctr Esophageal Dis, Dallas, TX USA

[5] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[6] Univ Kansas, Ctr Canc, Div Gastroenterol & Hepatol, Kansas City, KS 66103 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2024年 / 211卷

关键词：

D O I：

10.1016/j.ejca.2024.114872

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PB347

引用

页码：S136 / S136

页数：1

共 21 条

[1] DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (01) : 424 - 435
[2] DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells
Duskova, Katerina
Lejault, Pauline
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Guillot, Régis
Britton, Sébastien
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Journal of the American Chemical Society, 2020, 142 (01): : 424 - 435
[3] PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells
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[4] DNA damage generated by transcription-replication conflicts explains the synthetic lethality of PARP inhibitors with homologous recombination deficiency
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[5] DNA Damage in CD133-Positive Cells in Barrett's Esophagus and Esophageal Adenocarcinoma
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[6] Targeting the DNA Damage Response Pathway by Combination of ATR and PARP Inhibition Imparts Synthetic Lethality to Cervical Cancer Cells
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[7] JQ1 induces DNA damage, inhibits expression of DNA repair proteins, and synergizes with PARP inhibitors in pancreatic cancer cells
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Council, Leona
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[8] DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors
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[9] Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition
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[10] PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies
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CANCER RESEARCH COMMUNICATIONS, 2023, 3 (11): : 2233 - 2243

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