Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates

被引：0
|
作者：
Xahuentitla, Hugo Pilotzi [1 ]
Montes, Jesus Guadalupe Ortega [1 ]
Medina, Dino Hernan Gnecco [1 ]
Vazquez, Joel Luis Teran [1 ]
Nunez, Emanuel Hernandez [2 ]
Flores, Maria Laura Orea [1 ]
机构：
[1] Benemerita Univ Autonoma Puebla, Ctr Quim, Inst Ciencias, Edif IC Complejo Ciencias C U, Zaragoza 72570, Puebla, Mexico
[2] Inst Tecnol Super Calkini Estado Campeche ITESCAM, Dept Estudios Posgrad & Invest, Av AH Canun S N San Felipe, Calkini 24900, Mexico
来源：
MOLBANK | 2024年 / 2024卷 / 04期
关键词：
asymmetric synthesis; <italic>N</italic>-acryloyl-4-phenyloxazolidine; (<italic>R</italic>)-(-)-2-phenylglycinol; methyl propiolate; DIASTEREOSELECTIVE SYNTHESIS; OXAZOLIDINES; LACTAMS;
D O I：
10.3390/M1903
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The chiral oxazolidine moiety is an important core in asymmetric synthesis due to its ability to participate in various stereoselective chemical reactions and because it forms part of more complex and important active compounds. Therefore, in this letter we report a convenient diastereoselective and practical strategy for the synthesis of chiral methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates, starting from (R)-(-)-2-phenylglycinol and methyl propiolate, which were obtained via two simple chemical and stereoselective reactions.
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页数：7
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