An Insight into the Roles of Zona Pellucida in Growth and Development of Mammalian Ocytes and Embryos: Changes of Age-related and Cryopreservation: A Review

被引：0

作者：

Mohammed, A. A. ^{[1
]}

Al-Suwaiegh, S. ^{[1
]}

Al-Gherair, I. ^{[1
]}

机构：

[1] King Faisal Univ, Coll Agr & Food Sci, Dept Anim & Fish Prod, POB 402, Al Hasa 31982, Saudi Arabia

来源：

INDIAN JOURNAL OF ANIMAL RESEARCH | 2024年 / 58卷 / 10期

关键词：

Aging; Embryos development; Follicles; Gene expression; Oocytes morphology; Zona pellucida; IN-VITRO FERTILIZATION; GENE-EXPRESSION; BOVINE EMBRYOS; HUMAN OOCYTE; PROTEINS; QUALITY; SPERM; BIREFRINGENCE; INFERTILITY; COMPETENCE;

D O I：

10.18805/IJAR.BF-1812

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The zona pellucida (ZP) is a extracellular transparent coat surrounding the oocyte and preimplantation embryo in mammals. The ZP separates between the surrounding cumulus cells and oocyte. It plays a pivotal role in oocyte growth and fertilization and early embryo development. Zona pellucida formation and glycoproteins, roles of ZP on female fertility and infertility, ZP micromanipulation on embryo development and changes of ZP upon vitrification of oocytes is discussed. Zona pellucida is formed of glycoproteins during ovarian follicle growth and development. It protects the oocyte from physical or chemical damage, initiates fertilization, prevents polyspermy and supports early embryonic development. The ZP is responsible for recognition between oocytes and sperm. Mutations in glycoproteins cause female infertility characterized by empty follicle syndrome and oocyte degeneration. The ZP removal is detrimental for embryo implantation. Furthermore, there is a biophysical role of ZP during vitrification of oocytes. Hence, the current review article was designed to collect, discuss and highlight the characters of zona pellucida, roles in female fertility and infertility, ZP micromanipulation on embryo development and changes of ZP upon vitrification.

引用

页码：1642 / 1650

页数：9