As a key factor driving economic growth, the connotation and extension of new quality productivity have been expanding. This has a profound impact on the path of total factor productivity improvement. Therefore, this paper combines the qualitative comparative analysis (QCA), necessary conditions analysis (NCA), and data envelopment analysis (DEA) methods and adopts a group study to analyze the driving mechanism of total factor productivity (TFP) enhancement in 30 provinces in China from the perspective of new quality productivity. The study finds that (1) a single new quality productivity component does not constitute a necessary condition for TFP; (2) three new types of ecological factors can drive regions to realize high total factor productivity, including innovation-driven, green-led, and service-embedded factors, reflecting the complex mechanism of high-quality development in China's provinces; and (3) the high factor productivities of the eastern, central, and western regions are clearly differentiated, with different grouping paths, which are manifested in the "leading" development of the east, the "following" development of the center, and the "accompanying" development of the west, revealing the regional "leading" development and the "accompanying" development and showing the diversified path of regional high-quality development.This study not only deepens our understanding of the relationship between new quality productivity and total factor productivity in theory, but also provides scientific basis and decision support for different regions to formulate differentiated high-quality development strategies empirically.