Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024

被引：0
|
作者：
Sun, Wanying [1 ]
Choy, Ka Tim [1 ]
Cheng, Ka Man [1 ]
Brackman, Christopher [2 ]
Cheng, Samuel M. S. [1 ]
Sit, Thomas H. C. [2 ]
Tse, Anne C. N. [2 ]
Sims, Leslie D. [3 ]
Gu, Haogao [1 ]
Tang, Amy W. Y. [1 ]
Wong, Andrew N. C. [1 ]
Tsang, Andrew T. L. [1 ]
Koo, Joe C. T. [1 ]
Luk, Leo L. H. [1 ]
Yen, Hui-Ling [1 ]
Peris, Malik [1 ,4 ,5 ,6 ]
Poon, Leo L. M. [1 ,4 ,5 ,6 ]
机构：
[1] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Govt Hong Kong Special Adm Reg HKSARG, Hong Kong, Peoples R China
[3] Asia Pacific Vet Informat Serv, Melbourne, Vic, Australia
[4] Ctr Immunol & Infect, Hong Kong, Peoples R China
[5] Univ Hong Kong, HKU Pasteur Res Pole, Hong Kong, Peoples R China
[6] Univ Hong Kong, HKJC Global Hlth Inst, Hong Kong, Peoples R China
来源：
EUROSURVEILLANCE | 2025年 / 30卷 / 01期
关键词：
A VIRUS; BEARING; BIRDS;
D O I：
10.2807/1560-7917.ES.2025.30.1.2400839
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR, 2021-2024. Viruses from two spoon- bills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhib- ited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was detected in 63 age-stratified human sera, suggesting potential risk should the virus adapt to humans.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021
    Edwards, Kimberly M.
    Siegers, Jurre Y.
    Wei, Xiaoman
    Aziz, Ammar
    Deng, Yi-Mo
    Yann, Sokhoun
    Bun, Chan
    Bunnary, Seng
    Izzard, Leonard
    Hak, Makara
    Thielen, Peter
    Tum, Sothyra
    Wong, Frank
    Lewis, Nicola S.
    James, Joe
    Claes, Filip
    Barr, Ian G.
    Dhanasekaran, Vijaykrishna
    Karlsson, Erik A.
    EMERGING INFECTIOUS DISEASES, 2023, 29 (01) : 170 - 174
  • [2] Spreading of the High-Pathogenicity Avian Influenza (H5N1) Virus of Clade 2.3.4.4b into Uruguay
    Marandino, Ana
    Tomas, Gonzalo
    Panzera, Yanina
    Leizagoyen, Carmen
    Perez, Ramiro
    Bassetti, Lucia
    Negro, Raul
    Rodriguez, Sirley
    Perez, Ruben
    VIRUSES-BASEL, 2023, 15 (09):
  • [3] Pathogenicity in Chickens and Turkeys of a 2021 United States H5N1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b Wild Bird Virus Compared to Two Previous H5N8 Clade 2.3.4.4 Viruses
    Pantin-Jackwood, Mary J.
    Spackman, Erica
    Leyson, Christina
    Youk, Sungsu
    Lee, Scott A.
    Moon, Linda M.
    Torchetti, Mia K.
    Killian, Mary L.
    Lenoch, Julianna B.
    Kapczynski, Darrell R.
    Swayne, David E.
    Suarez, David L.
    Takada, Ayato
    VIRUSES-BASEL, 2023, 15 (11):
  • [4] An Update on Highly Pathogenic Avian Influenza A(H5N1) Virus, Clade 2.3.4.4b
    Webby, Richard J.
    Uyeki, Timothy M.
    JOURNAL OF INFECTIOUS DISEASES, 2024, 230 (03): : 533 - 542
  • [5] Re-Invasion of H5N8 High Pathogenicity Avian Influenza Virus Clade 2.3.4.4b in Hokkaido, Japan, 2020
    Isoda, Norikazu
    Twabela, Augustin T.
    Bazarragchaa, Enkhbold
    Ogasawara, Kohei
    Hayashi, Hirotaka
    Wang, Zu-Jyun
    Kobayashi, Daiki
    Watanabe, Yukiko
    Saito, Keisuke
    Kida, Hiroshi
    Sakoda, Yoshihiro
    VIRUSES-BASEL, 2020, 12 (12):
  • [6] Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Poultry, Benin, 2021
    Sanogo, Idrissa Nonmon
    Djegui, Fidelia
    Akpo, Yao
    Gnanvi, Corneille
    Dupre, Gabriel
    Rubrum, Adam
    Jeevan, Trushar
    McKenzie, Pamela
    Webby, Richard J.
    Ducatez, Mariette F.
    EMERGING INFECTIOUS DISEASES, 2022, 28 (12) : 2534 - 2537
  • [7] Emergence of High Pathogenicity Avian Influenza Virus H5N1 Clade 2.3.4.4b in Wild Birds and Poultry in Botswana
    Letsholo, Samantha L.
    James, Joe
    Meyer, Stephanie M.
    Byrne, Alexander M. P.
    Reid, Scott M.
    Settypalli, Tirumala B. K.
    Datta, Sneha
    Oarabile, Letlhogile
    Kemolatlhe, Obakeng
    Pebe, Kgakgamatso T.
    Mafonko, Bruce R.
    Kgotlele, Tebogo J.
    Kumile, Kago
    Modise, Boitumelo
    Thanda, Carter
    Nyange, John F. C.
    Marobela-Raborokgwe, Chandapiwa
    Cattoli, Giovanni
    Lamien, Charles E.
    Brown, Ian H.
    Dundon, William G.
    Banyard, Ashley C.
    VIRUSES-BASEL, 2022, 14 (12):
  • [8] Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China
    Yang, Jing
    Zhang, Chunge
    Yuan, Yue
    Sun, Ju
    Lu, Lu
    Sun, Honglei
    Sun, Heting
    Chu, Dong
    Qin, Siyuan
    Chen, Jianjun
    Zhang, Chengbo
    Hao, Xiyan
    Shi, Weifeng
    Liu, Wenjun
    Gao, George F.
    Digard, Paul
    Lycett, Samantha
    Bi, Yuhai
    EMERGING INFECTIOUS DISEASES, 2023, 29 (06) : 1244 - 1249
  • [9] Intraductal infection with H5N1 clade 2.3.4.4b influenza virus
    Roubidoux, Ericka Kirkpatrick
    Meliopoulos, Victoria
    Livingston, Brandi
    Brigleb, Pamela H.
    Schultz-Cherry, Stacey
    JOURNAL OF VIROLOGY, 2025, 99 (03)
  • [10] Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021
    Tian, Jingman
    Bai, Xiaoli
    Li, Minghui
    Zeng, Xianying
    Xu, Jia
    Li, Peng
    Wang, Miao
    Song, Xingdong
    Zhao, Zhiguo
    Tian, Guobin
    Liu, Liling
    Guan, Yuntao
    Li, Yanbing
    Chen, Hualan
    EMERGING INFECTIOUS DISEASES, 2023, 29 (07) : 1367 - 1375
12345