Kidney Injury in Patient with Non-small-cell Lung Cancer Receiving Tepotinib

被引：0

作者：

Oda, Naohiro ^{[1
]}

Onishi, Akifumi ^{[1
]}

Mitani, Reo ^{[1
]}

Tokura, Takehiko ^{[1
]}

Takata, Ichiro ^{[1
]}

机构：

[1] Fukuyama City Hosp, Dept Internal Med, Fukuyama, Japan

来源：

INTERNAL MEDICINE | 2024年

关键词：

non-small-cell lung cancer; tepotinib; kidney injury; tubulointerstitial nephritis; elevated serum creatinine;

D O I：

10.2169/internalmedicine.4488-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a 68-year-old man with advanced non-small-cell lung cancer treated with tepotinib who showed marked general edema, hypoalbuminemia, and an elevated serum creatinine level. Although tepotinibinduced kidney injury due to creatinine transporter inhibition has been reported, renal biopsy findings suggested tubulointerstitial injury due to decreased renal blood flow, likely secondary to refractory fluid retention. This case highlights the potential for true kidney injury during tepotinib therapy and underscores the importance of careful monitoring and management of adverse renal effects.

引用

页数：5

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