A novel manual rotating fluid control mechanism in a microfluidic device with a finger-actuated pump for dual-mode sweat sampling

被引：0

作者：

Gama, Mohamed Ishag Hassan ^{[1
,2
]}

Abdullahi, Saminu ^{[1
,2
]}

Omer, Marwa Omer Mohammed ^{[1
,2
]}

Yang, Zhu ^{[3
]}

Wang, Xuzhong ^{[1
,2
]}

Osman, Yousuf Babiker M. ^{[1
,2
]}

Liu, Yuhang ^{[1
]}

Li, Jingzhen ^{[1
,2
]}

Li, Yingtian ^{[1
]}

Gao, Xing ^{[1
]}

Nie, Zedong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Univ Nottingham, Ningbo 315100, Peoples R China

来源：

LAB ON A CHIP | 2025年

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

VALVES; SKIN; SOFT;

D O I：

10.1039/d5lc00171d

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Wearable sweat analysis using microfluidics offers a non-invasive approach for real-time health monitoring, with applications in chronic disease management, athletic performance optimization, and early-stage condition detection. However, most existing wearable sweat microfluidic devices are limited to single-mode operation either real-time or on-demand sampling and often lack precise control over sample volume, which compromises analytical accuracy and utility. To address these limitations, we present a novel wearable microfluidic device featuring a manual rotating fluid control mechanism and a finger-actuated pump for dual-mode sweat sampling. The rotational control mechanism directs sweat either into detection chambers for volume-independent sensor reactions or through the finger-actuated pump for precise volume control. The pump incorporates a dedicated collection chamber, enabling sweat accumulation and controlled delivery in a single actuation, ensuring reproducible sample volumes and facilitating on-demand analysis when required. Additionally, the device integrates two reaction chambers for simultaneous dual biomarker detection. Performance validation during a 40 minute exercise session, using a colorimetric glucose assay, demonstrated reliable sweat sampling and on-demand biochemical analysis. These results highlight the device's potential as a practical tool for personalized health monitoring and field applications.

引用

页数：15