Magnetic vortex iron oxide nanorings coated with mesoporous silica as smart diagnostic and therapeutic nanoagents: Negative MRI-guided tumor magnetothermal-chemotherapy

被引：1

作者：

Wang, Jing ^{[1
]}

Li, Xueao ^{[1
]}

Zhao, Wenqian ^{[1
]}

Tu, Hui ^{[1
]}

Zu, Xiangyang ^{[1
]}

Li, Guangda ^{[1
]}

Li, Jinghua ^{[1
]}

Li, Jing ^{[2
]}

Zhuang, Yuchuan ^{[3
]}

Dong, Yanbo ^{[4
]}

Tulupov, Andrey ^{[5
]}

Zhang, Fengshou ^{[1
]}

Bao, Jianfeng ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Sch Med Technol & Engn, Luoyang 471023, Peoples R China

[2] Henan Univ Sci & Technol, Off Sci & Technol, Luoyang, Peoples R China

[3] Univ Rochester, Med Ctr, Dept Imaging Sci, Rochester, NY 14627 USA

[4] Pingdingshan Univ, Fac Teacher Educ, Pingdingshan 497000, Peoples R China

[5] Russian Acad Sci, Lab MRT technol, Inst Int Tomog Ctr, Institutskaya Str 3A, Novosibirsk 630090, Russia

来源：

MATERIALS TODAY COMMUNICATIONS | 2025年 / 44卷

基金：

中国国家自然科学基金;

关键词：

Magnetic vortex iron oxide nanorings; Magnetic hyperthermia therapy; Tumor multifunctional therapeutic platform; Chemotherapy; Negtive enhanced MRI; LARGE-SCALE SYNTHESIS; CANCER-THERAPY; DRUG-DELIVERY; NANOPARTICLES; HYPERTHERMIA; TOXICITY; CARRIERS;

D O I：

10.1016/j.mtcomm.2025.111966

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Encapsulated magnetic vortex iron oxide nanorings (MVIONs) within mesoporous silica (MVIONs@SiO2) have been developed to address key challenges in magnetic hyperthermia-specifically, controlled drug release and precise thermal management in tumor therapy. This study showcases the design of these nanoparticles for the targeted delivery of the chemotherapeutic agent doxorubicin (DOX), facilitated by alternating magnetic fields (AMF). The MVIONs@SiO2 nanoparticles exhibit exceptional specific absorption rates (SAR) of approximately 1021 W center dot g- 1, indicating high thermal efficiency that ensures effective tumor heating without harming surrounding tissues. Additionally, these nanoparticles achieve a DOX loading capacity of 23.4 % and a release rate of 60 % under magnetic heating conditions, optimizing drug delivery to the tumor site. The relaxation rate r2 of MVIONs@SiO2 is recorded at 53.32 mM- 1s- 1, demonstrating significant MRI contrast enhancement correlating with nanoparticle concentration within tumors. Experimental results from cell and animal studies confirm the biocompatibility and potent antitumor activity of MVIONs@SiO2, highlighting its dual function in improving chemotherapy and magnetic hyperthermia. This innovation in nanoparticle-based theranostics marks a significant advance in integrating diagnostic imaging and therapeutic heating, potentially revolutionizing cancer treatment and diagnostics.

引用

页数：13