Empagliflozin, an SGLT2 inhibitor, prevented palmitate-induced lipotoxicity through enhanced fatty acid oxidation and reduced stress signals

被引：0

作者：

Kim, T. ^{[1
]}

Kim, Y. ^{[2
,3
]}

Park, S. ^{[2
,3
]}

Kim, Y. ^{[2
,3
]}

Choi, S. -E. ^{[2
]}

Son, Y. ^{[2
,3
]}

An, S. ^{[4
]}

Jeon, J. ^{[2
]}

Lee, N. ^{[2
]}

Han, S. ^{[2
]}

Kim, H. ^{[2
]}

Kim, D. ^{[2
]}

Lee, K. -W. ^{[2
]}

机构：

[1] Seoul Med Ctr, Div Endocrinol & Metab, Seoul, South Korea

[2] Ajou Univ, Dept Endocrinol & Metab, Suwon, South Korea

[3] Ajou Univ, Dept Biomed Sci, Suwon, South Korea

[4] Isam Hosp, Dept Endocrinol & Metab, Busan, South Korea

来源：

DIABETOLOGIA | 2024年 / 67卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

654

引用

页码：S315 / S315

页数：1

共 13 条

[1] SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations
Lee, Han Byeol
Choi, Sunge
Kang, Yup
Kim, Tae Ho
Lee, Nami
Moon, Hyun Uk
Han, Seung Jin
Kim, Dae Jung
Lee, Kwanwoo
DIABETES, 2019, 68
[2] Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells
Song, Min-Woo
Cui, Wenhao
Lee, Chang-Gun
Cui, Rihua
Son, Young Ho
Kim, Young Ha
Kim, Yujin
Kim, Hae Jin
Choi, Sung-E.
Kang, Yup
Kim, Tae Ho
Jeon, Ja Young
Lee, Kwan-Woo
FRONTIERS IN PHARMACOLOGY, 2023, 14
[3] The Effects of the SGLT2 Inhibitor Empagliflozin on Fatty Liver in Diet-Induced Obese Mice
Wang, Wei
Guo, Wanrong
Jian, Ying
Shen, Yunfeng
Xu, Fen
DIABETES, 2020, 69
[4] Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses
Dmitry Namgaladze
Sebastian Lips
Thomas J. Leiker
Robert C. Murphy
Kim Ekroos
Nerea Ferreiros
Gerd Geisslinger
Bernhard Brüne
Diabetologia, 2014, 57 : 1067 - 1077
[5] Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses
Namgaladze, Dmitry
Lips, Sebastian
Leiker, Thomas J.
Murphy, Robert C.
Ekroos, Kim
Ferreiros, Nerea
Geisslinger, Gerd
Bruene, Bernhard
DIABETOLOGIA, 2014, 57 (05) : 1067 - 1077
[6] PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation
Cao, Mingming
Tong, Yuzhen
Lv, Qingguo
Chen, Xiang
Long, Yang
Jiang, Li
Wan, Jun
Zhang, Yuwei
Zhang, Fang
Tong, Nanwei
PPAR RESEARCH, 2012, 2012
[7] CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation
Yang, Won-Mo
Lee, Wan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 452 (03) : 715 - 721
[8] PPARδ Protects Pancreatic Beta-Cells from Palmitate-Induced Endoplasmic Reticulum Stress by Promoting Fatty Acid Oxidation
Cao, Mingming
Tong, Yuzhen
Lv, Qingguo
Long, Yang
Wan, Jun
Jiang, Li
Tong, Nanwei
DIABETES, 2012, 61 : A524 - A524
[9] Palmitate-induced cardiac lipotoxicity is relieved by Quercetin and its novel acetylated derivative Q2 through inhibition of oxidative stress and inflammation
Granieri, Maria Concetta
Rocca, Carmine
De Bartolo, Anna
Nettore, Immacolata Cristina
Rago, Vittoria
Romeo, Naomi
Ceramella, Jessica
Mariconda, Annaluisa
Macchia, Paolo Emidio
Ungaro, Paola
Sinicropi, Maria Stefania
Angelone, Tommaso
VASCULAR PHARMACOLOGY, 2024, 155 : 107323
[10] SGLT2 Inhibitor Empagliflozin Increases Fatty Acid Oxidation, Coupling Between Glycolysis and Glucose Oxidation, and Decreases Left Ventricular Hypertrophy in Mice With Hypertrophic Cardiomyopathy Due to Myosin R403Q Mutation
Baka, Tomas
Moore, Jarrod
Qin, Fuzhong
He, Huamei
Chambers, Jordan M.
Croteau, Dominique
Goel, Raghuveera
Zhang, Aifeng
Smith, Hunter
Balschi, James A.
Pimentel, David R.
Seidman, Christine E.
Seidman, Jonathan G.
Emili, Andrew
Colucci, Wilson S.
Luptak, Ivan
CIRCULATION, 2023, 148

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