Production of therapeutic radionuclides for bone-seeking radiopharmaceuticals to meet clinical exigency and academic research

被引：0
|
作者：
Dash, Ashutosh [1 ]
Das, Tapas [1 ,2 ]
机构：
[1] Bhabha Atom Res Ctr, Radiopharmaceut Div, Mumbai 400085, India
[2] Homi Bhabha Natl Inst, Mumbai 400094, India
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2025年
关键词：
Bone pain palliation; Radiopharmaceuticals; Bisphosphonates; Radionuclide production; Radiochemical processing; Good manufacturing practices; DIRECT NEUTRON-ACTIVATION; RESISTANT PROSTATE-CANCER; POTENTIAL AGENTS; QUALITY-CONTROL; EXTRACTION CHROMATOGRAPHY; PALLIATIVE RADIOTHERAPY; MARROW-TRANSPLANTATION; PRODUCTION LOGISTICS; SKELETAL METASTASES; REACTOR PRODUCTION;
D O I：
10.1007/s10967-025-10025-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This review offers a comprehensive and insightful overview of the production of therapeutic radionuclides (32P, 89Sr, 117mSn, 153Sm, 166Ho, 186Re, 188Re, 177Lu and 223Ra), which are essential for developing bone-targeting radiopharmaceuticals. These radionuclides are critical not only in the early stages of radiopharmaceutical development but also in ensuring their continued success, reliability, and progress. The manuscript highlights recent innovations and trends in the field, addressing significant challenges and emerging opportunities. It also examines the regulatory environment and emphasizes the growing role of automation in enhancing the production process.
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页码：2591 / 2611
页数：21
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