Isatuximab, Plus Bortezomib, Lenalidomide, and Dexamethasone (VRd) for Newly Diagnosed Multiple Myeloma (NDMM) Transplant-ineligible Patients: Frailty Subgroup Analysis of IMROZ

被引:0
|
作者
Manier, Salomon [1 ]
Dimopoulos, Meletios-Athanasios [2 ]
Leleu, Xavier [3 ]
Moreau, Philippe [4 ]
Cavo, Michele [5 ]
Goldschmidt, Hartmut [6 ]
Orlowski, Robert Z. [7 ]
Tron, Muriel [8 ]
Tekle, Christina [8 ]
Bregeault, Marie-France [9 ]
Shafer, Andrea [8 ]
Beksac, Meral [10 ]
Facon, Thierry [11 ]
机构
[1] Univ Hosp Ctr Lille, Dept Hematol, Lille, France
[2] Univ Athens, Sch Med, Athens, Greece
[3] CHU Poitiers, Poitiers, France
[4] Univ Hosp Hotel Dieu, Hematol Dept, Paris, France
[5] Univ Bologna, IRCCS Azienda Osped Univ Bologna, Ist Ematol Seragnoli, Bologna, Italy
[6] Univ Hosp Heidelberg, Dept Internal Med 5, GMMG Study Grp, Heidelberg, Germany
[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[8] Sanofi, Baltimore, MD USA
[9] Sanofi, R&D, Vitry Sur Seine, France
[10] Istinye Univ, Ankara Liv Hosp, Ankara, Turkiye
[11] Univ Lille, CHU Lille, Serv Malad Sang, Lille, France
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P-426
引用
收藏
页码:S290 / S291
页数:2
相关论文
共 50 条
  • [1] Isatuximab Plus Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) Versus Vrd in Chinese Patients with Newly Diagnosed Multiple Myeloma Who Are Ineligible for Transplant: IMROZ Subgroup Analysis
    An, Gang
    Liu, Zhuogang
    Jin, Jie
    Cai, Zhen
    Li, Wei
    Xia, Zhongjun
    Cen, Xinan
    Hu, Yu
    Mi, Jian-Qing
    Jing, Hongmei
    Zhan, Rong
    Qu, Xiaoyan
    Du, Xin
    Gao, Dan
    Zhao, Liang
    Qiu, Lugui
    BLOOD, 2024, 144 : 7055 - 7056
  • [2] Phase III (IMROZ) study design: Isatuximab plus bortezomib (V), lenalidomide (R), and dexamethasone (d) vs VRd in transplant-ineligible patients (pts) with newly diagnosed multiple myeloma (NDMM).
    Orlowski, Robert Z.
    Goldschmidt, Hartmut
    Cavo, Michele
    Martin, Thomas G.
    Paux, Gautier
    Oprea, Corina
    Facon, Thierry
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [3] Phase 3 study results of isatuximab, bortezomib, lenalidomide, and dexamethasone (Isa-VRd) versus VRd for transplant-ineligible patients with newly diagnosed multiple myeloma (IMROZ).
    Facon, Thierry
    Dimopoulos, Meletios Athanasios
    Leleu, Xavier P.
    Beksac, Meral
    Pour, Ludek
    Hajek, Roman
    Liu, Zhuogang
    Minarik, Jiri
    Moreau, Philippe
    Romejko-Jarosinska, Joanna
    Spicka, Ivan
    Vorobyev, Vladimir I.
    Cavo, Michele
    Goldschmidt, Hartmut
    Martin, Thomas G.
    Manier, Salomon
    Bregeault, Marie-France
    Mace, Sandrine
    Berthou, Christelle
    Orlowski, Robert Z.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [4] Phase 3 Study Results of Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) Versus VRd for Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma (IMROZ)
    Facon, Thierry
    Dimopoulos, Meletios
    Leleu, Xavier
    Beksac, Meral
    Pour, Ludek
    Hajek, Roman
    Liu, Zhuogang
    Minarik, Jiri
    Moreau, Philippe
    Romejko-Jarosinska, Joanna
    Spicka, Ivan
    Vorobyev, Vladimir
    Cavo, Michele
    Goldschmidt, Hartmut
    Martin, Thomas
    Manier, Salomon
    Bregeault, Marie-France
    Mace, Sandrine
    Berthou, Christelle
    Orlowski, Robert
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S31 - S31
  • [5] Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA
    Facon, Thierry
    Cook, Gordon
    Usmani, Saad Z.
    Hulin, Cyrille
    Kumar, Shaji
    Plesner, Torben
    Touzeau, Cyrille
    Bahlis, Nizar J.
    Basu, Supratik
    Nahi, Hareth
    Goldschmidt, Hartmut
    Quach, Hang
    Mohty, Mohamad
    Venner, Christopher P.
    Weisel, Katja
    Raje, Noopur
    Hebraud, Benjamin
    Belhadj-Merzoug, Karim
    Benboubker, Lotfi
    Decaux, Olivier
    Manier, Salomon
    Caillot, Denis
    Ukropec, Jon
    Pei, Huiling
    Van Rampelbergh, Rian
    Uhlar, Clarissa M.
    Kobos, Rachel
    Zweegman, Sonja
    LEUKEMIA, 2022, 36 (04) : 1066 - 1077
  • [6] Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA
    Thierry Facon
    Gordon Cook
    Saad Z. Usmani
    Cyrille Hulin
    Shaji Kumar
    Torben Plesner
    Cyrille Touzeau
    Nizar J. Bahlis
    Supratik Basu
    Hareth Nahi
    Hartmut Goldschmidt
    Hang Quach
    Mohamad Mohty
    Christopher P. Venner
    Katja Weisel
    Noopur Raje
    Benjamin Hebraud
    Karim Belhadj-Merzoug
    Lotfi Benboubker
    Olivier Decaux
    Salomon Manier
    Denis Caillot
    Jon Ukropec
    Huiling Pei
    Rian Van Rampelbergh
    Clarissa M. Uhlar
    Rachel Kobos
    Sonja Zweegman
    Leukemia, 2022, 36 : 1066 - 1077
  • [7] Isatuximab Plus Lenalidomide and Dexamethasone With Bortezomib Versus Isatuximab Plus Lenalidomide and Dexamethasone in Newly Diagnosed Transplant Ineligible Multiple Myeloma: The Benefit Study
    Leleu, Xavier
    Hulin, Cyrille
    Lambert, Jerome
    Bobin, Arthur
    Perrot, Aurore
    Manier, Salomon
    Jaccard, Arnaud
    Montes, Lydia
    Karlin, Lionel
    Godmer, Pascal
    Chalopin, Thomas
    Slama, Borhane
    Chretien, Marie Lorraine
    Laribi, Karim
    Dingremont, Claire
    Roul, Christophe
    Mariette, Clara
    Rigaudeau, Sophie
    Macro, Margaret
    Mohty, Mohamad
    Touzeau, Cyrille
    Moreau, Philippe
    Avet-Loiseau, Herve
    Corre, Jill
    Facon, Thierry
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S33 - S33
  • [8] Daratumumab Plus Lenalidomide and Dexamethasone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Maia Age Subgroup Analysis
    Facon, Thierry
    Kumar, Shaji K.
    Weisel, Katja
    Usmani, Saad
    Moreau, Philippe
    Plesner, Torben
    Orlowski, Robert Z.
    Bahlis, Nizar Jacques
    Basu, Supratik
    Nahi, Hareth
    Hulin, Cyrille
    Quach, Hang
    O'Dwyer, Michael
    Perrot, Aurore
    Venner, Christopher P.
    Raje, Noopur
    Tiab, Mourad
    Macro, Margaret
    Frenzel, Laurent
    Leleu, Xavier
    Pei, Huiling
    Carson, Robin
    Borgsten, Fredrik
    Goldschmidt, Hartmut
    BLOOD, 2022, 140 : 10133 - 10136
  • [9] Updates from a phase Ib study of isatuximab (Isa), bortezomib (V) and dexamethasone (D) plus cyclophosphamide (C) or lenalidomide (R) in transplant-ineligible, newly diagnosed multiple myeloma (NDMM).
    Ocio, Enrique M.
    Rodriguez Otero, Paula
    Bringhen, Sara
    Oliva, Stefania
    Nogai, Axel
    Attal, Michel
    Moreau, Philippe
    Martinez-Lopez, Joaquin
    Le Roux, Nadia
    Mace, Sandrine
    Rouchon, Marie-Claude
    Wang, Qiuyan
    Mateos, Maria-Victoria
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [10] Phase 3 randomized study of isatuximab (Isa) plus lenalidomide and dexamethasone (Rd) with bortezomib versus isard in patients with newly diagnosed transplant ineligible multiple myeloma (NDMM TI).
    Leleu, Xavier P.
    Hulin, Cyrille
    Lambert, Jerome
    Bobin, Arthur
    Manier, Salomon
    Perrot, Aurore
    Jaccard, Arnaud
    Montes, Lydia
    Karlin, Lionel
    Godmer, Pascal
    Chalopin, Thomas
    Slama, Borhane
    Laribi, Kamel
    Chretien, Marie-Lorraine
    Mohty, Mohamad
    Touzeau, Cyrille
    Moreau, Philippe
    Avet-Loiseau, Herve
    Corre, Jill
    Facon, Thierry
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)