[1] Sinai Hlth, Dept Pharm, Toronto, ON, Canada
[2] Sinai Hlth, Dept Med, Toronto, ON, Canada
[3] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada
[4] Univ Toronto, Interdept Div Crit Care, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Toronto, ON, Canada
[6] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada
[7] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[8] Univ Toronto, Dept Anesthesiol & Pain Med, Toronto, ON, Canada
[9] Sunnybrook Hlth Sci Ctr, Dept Crit Care Med, Toronto, ON, Canada
[10] Sunnybrook Res Inst, Toronto, ON, Canada
[11] Sunnybrook Hlth Sci Ctr, ICES, Toronto, ON, Canada
[12] Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Pall, London, England
[13] Univ Montreal, Fac Pharm, Montreal, PQ, Canada
[14] Hop Sacre Coeur Montreal, Dept Pharm, Montreal, PQ, Canada
[15] Ctr Integre Univ Sante & Serv Nord De Ile De Mont, Res Ctr, Montreal, PQ, Canada
[16] Weill Cornell Med, Dept Anesthesiol, New York, NY USA