Mechanistic insights into stem cell fate regulation via RNA methylation

被引：0
|
作者：
Sun, Yushuang [1 ]
Li, Jingting [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Inst Precis Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2025年 / 107卷
基金：
中国国家自然科学基金;
关键词：
Adult stem cells; RNA methylation; Self-renewal; Differentiation; M6A; M7G; M5C; And m1A; MESSENGER-RNA; GENE-EXPRESSION; SELF-RENEWAL; YTH DOMAIN; METHYLTRANSFERASE; REVEALS; N-6-METHYLADENOSINE; DEMETHYLATION; METHYLOME; DNMT2;
D O I：
10.1016/j.arr.2025.102717
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cells possess an extraordinary ability for self-renewal and differentiation, making them essential for tissue repair, regeneration, and anti-aging. RNA methylation is crucial in regulating stem cell fate by modulating gene expression. This review synthesizes current research on RNA methylation modifications, such as m6A, m7G, m5C, and m1A, and their impact on adult stem cell fate. It provides a comprehensive overview of the molecular machinery involved in RNA methylation, emphasizes the critical roles of these modifications in stem cell biology, reviews the latest advancements in sequencing technologies, and discusses potential crosstalk between RNA methylation and epigenetic mechanisms.
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页数：10
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