Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology

被引：0
|
作者：
Huang, Yongjiao [1 ,3 ]
He, Wei [1 ,4 ,5 ]
Zhang, Yingting [1 ]
Zou, Zhihui [1 ]
Han, Longchuan [1 ]
Luo, Jing [1 ,4 ]
Wang, Yunqiu [6 ]
Tang, Xinxin [1 ]
Li, Yue [1 ]
Bao, Yuhan [7 ]
Huang, Ying [1 ]
Long, Xi-Dai [8 ]
Fu, Yinkun [1 ]
He, Ming [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Minist Educ, Shanghai Frontiers Sci Ctr Cellular Homeostasis &, Key Lab Cell Differentiat & Apoptosis,Sch Med,Dept, Shanghai, Peoples R China
[2] Youjiang Med Univ Nationalities, Affiliated Hosp, Dept Pathol, Baise, Peoples R China
[3] DeHong Vocat Coll, Sch Basic Med, Dehong, Yunnan, Peoples R China
[4] Kunming Med Univ, Sch Basic Med, Kunming, Peoples R China
[5] Sichuan Ctr Dis Control & Prevent, Toxicol Dept, Chengdu, Sichuan, Peoples R China
[6] UCL, Dept Biomed Sci & Synthet Organ Chem, London, England
[7] Univ Auckland, Dept Biol Sci, Auckland, New Zealand
[8] Youjiang Med Univ Nationalities, Affiliated Hosp, Clinicopathol Diag & Res Ctr, Baise, Guangxi, Peoples R China
来源：
AGING AND DISEASE | 2025年
基金：
中国国家自然科学基金;
关键词：
Aging; SIRT2; Liver fibrosis; Renal fibrosis; Cardiac fibrosis; RENAL TUBULOINTERSTITIAL FIBROSIS; HEPATIC STELLATE CELLS; BREAST-CANCER CELLS; CELLULAR SENESCENCE; FIBROBLAST ACTIVATION; FATTY LIVER; MESENCHYMAL TRANSITION; INTERSTITIAL FIBROSIS; SIGNALING PATHWAYS; ENDOTHELIAL-CELLS;
D O I：
10.14336/AD.202.0513
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is a complex biological process that involves multi-level structural and physiological changes. Aging is a major risk factor for many chronic diseases. The accumulation of senescent cells changes the tissue microenvironment and is closely associated with the occurrence and development of tissue and organ fibrosis. Fibrosis is the result of dysregulated tissue repair response in the development of chronic inflammatory diseases. Recent studies have clearly indicated that SIRT2 is involved in regulating the progression of fibrosis, making it a potential target for anti-fibrotic drugs. SIRT2 is a NAD(+ )dependent histone deacetylase, shuttling between nucleus and cytoplasm, and is highly expressed in liver, kidney and heart, playing an important role in the occurrence and development of aging and fibrosis. Therefore, we summarized the role of SIRT2 in liver, kidney and cardiac fibrosis during aging.
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页数：18
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