The effect of laparoscopic sleeve gastrectomy on metabolic syndrome parameters during one year of follow-up

Objective: We aimed to evaluate the effectiveness of laparoscopic sleeve gastrectomy (LSG) as a treatment method for morbid obesity and its impact on reducing the incidence of metabolic syndrome and its components. Patients and Methods: This retrospective and a single-center study included patients with obesity who underwent LSG and were followed up at an endocrinology and metabolism outpatient clinic for at least one year. Anthropometric measurements, blood pressure, and blood examinations including fasting plasma glucose and lipid profile were assessed before the surgery and one year after the surgery. The presence of metabolic syndrome and related comorbidities was documented. Results: The study included 62 patients, with a mean age of 38.2 +/- 8 years and a female predominance (88.7%). At one year post-surgery, significant improvements were observed in body weight, waist circumference, blood pressure, and metabolic parameters (P<0.001 for all). The prevalence of metabolic syndrome decreased from 66.1% to 6.5% (P<0.001). The prevalence of diabetes, hypertension, and hepatosteatosis also decreased significantly (P<0.05). Conclusion: Laparoscopic sleeve gastrectomy demonstrates substantial weight loss and positive effects on metabolic syndrome components. The procedure appears to be an effective intervention for obese patients with obesity-related comorbidities. Longer-term prospective studies are needed to further validate these promising results.