Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses

被引：0
|
作者：
Mehrani, Yeganeh [1 ]
Kakish, Julia E. [1 ]
Napoleoni, Christina [1 ]
Thompson, Jennifer Jane [1 ]
Knapp, Jason P. [1 ]
Minott, Jessica A. [1 ]
Yates, Jacob G. E. [1 ]
Stuart, Deirdre [2 ]
Coomber, Brenda L. [3 ]
Foster, Robert A. [1 ]
Bridle, Byram W. [1 ]
Karimi, Khalil [1 ]
机构：
[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON, Canada
[2] Univ Guelph, Ontario Vet Coll, Compan Anim Tumour Bank, Guelph, ON, Canada
[3] Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON, Canada
来源：
VETERINARY AND COMPARATIVE ONCOLOGY | 2025年 / 23卷 / 01期
关键词：
cancer; canine mast cell tumours; oncolytic virotherapy; oncolytic viruses; SURVIVAL; ORFV;
D O I：
10.1111/vco.13024
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low-grade tumours. As a result, new treatment strategies are being sought. We tested the potential of several oncolytic viruses (OVs) to infect and kill a cell line isolated from a canine MCT. Employing a resazurin-based metabolic assay and flow cytometry technology, we used recombinant vesicular stomatitis virus (rVSV-Delta m51), avian orthoavulavirus-1 (AOaV-1), and Orf viruses in our assessment. Our study aimed to evaluate the potential of oncolytic virotherapy in treating canine cancers. We found that MCT-1 cells showed different sensitivities to the OVs, with rVSV-Delta m51 showing the most promising results in vitro. These findings suggest that further investigation into using OVs for treating canine MCTs is needed, although clinical efficacy is yet to be determined.
引用
收藏
页码：42 / 51
页数：10
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