Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments

被引：1

作者：

Quilez, Cristina ^{[1
,2
]}

Bebiano, Luis B. ^{[3
,4
]}

Jones, Eleri ^{[5
]}

Maver, Uros ^{[6
,7
]}

Meesters, Luca ^{[8
]}

Parzymies, Piotr ^{[5
]}

Petiot, Emma ^{[9
]}

Rikken, Gijs ^{[8
]}

Risueno, Ignacio ^{[1
,2
]}

Zaidi, Hamza ^{[9
]}

Zidaric, Tanja ^{[6
]}

Bekeschus, Sander ^{[10
,11
]}

van den Bogaard, Ellen H. ^{[8
]}

Caley, Matthew ^{[5
]}

Colley, Helen ^{[12
]}

Gago Lopez, Nuria ^{[13
]}

Letsiou, Sophia ^{[14
,15
]}

Marquette, Christophe ^{[9
]}

Maver, Tina ^{[6
,7
]}

Pereira, Ruben F. ^{[3
,4
,16
]}

Tobin, Desmond J. ^{[17
,18
]}

Velasco, Diego ^{[1
,2
]}

机构：

[1] Univ Carlos III Madrid, Bioengn Dept, Avda Univ 30, Leganes 28911, Madrid, Spain

[2] Fdn Jimenez Diaz, Fdn Inst Invest Sanitaria, Madrid, Spain

[3] Univ Porto, I3S Inst Invest & Inovacao Saude, Porto, Portugal

[4] Univ Porto, Inst Engn Biomed INEB, Porto, Portugal

[5] Queen Mary Univ London, Fac Med & Dent, Ctr Cell Biol & Cutaneous Res, Blizard Inst, London, England

[6] Univ Maribor, Inst Biomed Sci, Fac Med, Maribor, Slovenia

[7] Univ Maribor, Dept Pharmacol, Fac Med, Maribor, Slovenia

[8] Radboud Univ Nijmegen Med Ctr, Dept Dermatol, Nijmegen, Netherlands

[9] Univ Lyon 1, ICBMS, UMR5246, 3d FAB,CNRS,INSA,Univ Lyon,CPE Lyon, Villeurbanne, France

[10] Rostock Univ Med Ctr, Clin & Policlin Dermatol & Venerol, Rostock, Germany

[11] Leibniz Inst Plasma Sci & Technol INP Greifswald, ZIK Plasmatis, Greifswald, Germany

[12] Univ Sheffield, Sch Clin Dent, Sheffield, S Yorkshire, England

[13] Spanish Natl Canc Res Ctr CNIO, Mol Oncol Programme, Melanoma Grp, Madrid, Spain

[14] Univ West Attica, Dept Biomed Sci, Athens, Greece

[15] Univ West Attica, Dept Food Sci & Technol, Athens, Greece

[16] Univ Porto, ICBAS, Porto, Portugal

[17] Univ Coll Dublin, Charles Inst Dermatol, Dublin, Ireland

[18] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Conway, AR USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2024年 / 144卷 / 12期

基金：

荷兰研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

In vitro disease models; In vitro skin aging; In vitro skin models; Skin bioprinting; Skin on chip; DERMAL PAPILLA CELLS; JUNCTIONAL EPIDERMOLYSIS-BULLOSA; RECESSIVE CONGENITAL ICHTHYOSIS; RECONSTRUCTED HUMAN EPIDERMIS; ON-A-CHIP; EXTRACELLULAR-MATRIX; ATOPIC-DERMATITIS; STEM-CELLS; HUMAN KERATINOCYTES; GENE-EXPRESSION;

D O I：

10.1016/j.jid.2024.04.032

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.

引用

页码：2650 / 2670

页数：21

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