Rapid eye movement (REM)-related obstructive sleep apnea and hypertension: insights from the clinical spectrum of apnea-hypopnea index ratios across REM and non-REM sleep stages in a Chinese cohort

被引:0
|
作者
Wang, Yuxin [1 ]
Shi, Chuan [1 ]
Luo, Jinmei [1 ]
Huang, Rong [1 ]
Xiao, Yi [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Pulm & Crit Care Med, Peking Union Med Coll Hosp, 1 Shuaifuyuan, Beijing 100730, Peoples R China
关键词
hypertension; obstructive sleep apnea (OSA); rapid eye movement (REM) sleep; REM-OSA; SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE; ASSOCIATION; ARCHITECTURE; GUIDELINE; RELEVANCE; OSA;
D O I
10.1111/jsr.14418
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Previous studies have linked sleep-disordered breathing during rapid eye movement (REM) sleep to hypertension. However, no standardised definition of REM-related obstructive sleep apnea (REM-OSA) exists. This study aimed to evaluate whether the ratio of the apnea-hypopnea index (AHI) in REM to that in non-REM (NREM) (REM-AHI/NREM-AHI) accurately identifies patients with OSA comorbid with hypertension. We screened 1439 participants and included 790 patients with OSA. REM-OSA was defined as AHI >= 5 events/h, REM-AHI/NREM-AHI >= 2, and REM stage >= 30 min. Differences between REM-OSA and NREM-OSA groups, and among quartiles of REM-AHI/NREM-AHI, were assessed. The impact of REM-AHI/NREM-AHI on hypertension was assessed by logistic regression and restricted cubic spline analysis. Overall, patients with REM-OSA, as traditionally defined, had a lower hypertension prevalence, lower blood pressure, and milder OSA. Patients with REM-AHI/NREM-AHI <2 but a higher total AHI had a higher prevalence of hypertension. The highest REM-AHI/NREM-AHI quartile had the mildest OSA and the lowest hypertension prevalence. In subgroups restricted by total AHI or NREM-AHI, a similar trend existed, suggesting that total AHI appeared more influential on hypertension than the predominance of REM-AHI. Restricted cubic spline analysis certified a non-linear relationship between REM-AHI/NREM-AHI and total AHI, blood pressure and hypertension prevalence. Our research showed that patients with REM-OSA defined by REM-AHI/NREM-AHI >= 2 are not the subgroup with the highest hypertension prevalence within the entire OSA population. It is important to avoid focusing solely on the REM-AHI/NREM-AHI ratio and overlooking the overall severity of OSA, which could lead to missing groups that also have a high prevalence of hypertension.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] APNEA-HYPOPNEA EVENTS DURING REM/NON-REM SLEEP AND HYPERTENSION AMONG PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
    Ren, R.
    Zhang, Y.
    Yang, L.
    Tan, L.
    Li, T.
    Tang, X.
    SLEEP MEDICINE, 2019, 64 : S319 - S319
  • [2] APNEA-HYPOPNEA EVENTS DURING REM/NON-REM SLEEP AND HYPERTENSION AMONG PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
    Ren, Rong
    Zhang, Ye
    Yang, Linghui
    Tan, Lu
    Li, Taomei
    Tang, Xiangdong
    SLEEP, 2019, 42
  • [3] EAR OXIMETRY TO DETECT APNEA AND DIFFERENTIATE RAPID EYE-MOVEMENT (REM) AND NON-REM (NREM) SLEEP - SCREENING FOR THE SLEEP-APNEA SYNDROME
    FARNEY, RJ
    WALKER, LE
    JENSEN, RL
    WALKER, JM
    CHEST, 1986, 89 (04) : 533 - 539
  • [4] Effectiveness of oral appliances for obstructive sleep APNEA in rem vs. non-rem sleep
    Kirsch, D. B.
    Hirunwiwatkut, P.
    Palmisano, J.
    Consens, F. B.
    Chervin, R. D.
    SLEEP, 2006, 29 : A207 - A207
  • [5] Effects Of Hypoglossal Nerve Stimulation On Obstructive Sleep Apnea (osa) In Non-Rem And Rem Sleep
    Schwartz, A. R.
    Barnes, M.
    Hillman, D.
    Malhotra, A.
    Kezirian, E. J.
    Smith, P. L.
    Penzel, T.
    Parrish, D. A.
    Hoegh, T. B.
    Eastwood, P. R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [6] Association of Rapid Eye Movement Sleep (REM) Dominant Obstructive Sleep Apnea (OSA)(REM-OSA) Versus Non-REM Sleep Dominant OSA (non-REM OSA) and Suicidal Ideation in Posttraumatic Stress Disorder (PTSD)
    Gupta, Madhulika
    BIOLOGICAL PSYCHIATRY, 2020, 87 (09) : S144 - S144
  • [7] Rapid eye movement (REM) sleep related obstructive sleep apnea - Do we need to treat it?
    Bagai, K.
    Cutting, S. M.
    Song, Y.
    Wang, L.
    Malow, B. A.
    SLEEP, 2008, 31 : A200 - A200
  • [8] Rapid eye movement (REM) sleep related obstructive sleep apnea - A modifiable stroke risk factor
    Bagai, Kanika
    Cutting, Shawna M.
    Song, Yanna
    Wang, Lily
    Malow, Beth A.
    ANNALS OF NEUROLOGY, 2007, 62 (05) : 540 - 540
  • [9] Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea
    BaHammam, Ahmed S.
    Alshahrani, Mana
    Aleissi, Salih A.
    Olaish, Awad H.
    Alhassoon, Mohammed H.
    Shukr, Afnan
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [10] Obstructive sleep apnea during REM sleep and hypertension: new findings from a clinical cohort
    McCullough, Lindsay M.
    Mokhlesi, Babak
    SLEEP, 2023, 46 (03)