This research analyses a Brayton cycle power plant that utilizes waste as its energy source and an organic Rankine cycle. Integrating the Brayton cycle and the ORC, Apowered by incinerating municipal waste, is innovative. In this research, for the first time, a four-purpose survey was conducted on the waste incinerator power plant with Brayton cycle and gas turbine, and then it was carried out to optimize it. This study takes a significant step forward in advancing this technology through optimization. The energy and exergy analysis method was used to maximize the power of the power plant, the CEA method was used for economic analysis, and the genetic algorithm was used for optimization. The first step involves modeling the desired power plant, followed by calculations of exergy destruction, environmental cost, and construction cost. Subsequently, the system's exergy-economic and exergyenvironmental performance is evaluated. AFinally, the system optimizes power generation while minimizing pollution and cost. The results indicate that the powerAplant construction is not economically viable without considering its environmental benefits. The exergy destruction is calculated to be 95.75 $ per hour forAa plant with 4530 kW output power. With optimization, the exergy saving is 34.19%, Aand the total activity costs amount to 174.5 USD/GJ.