Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases

被引：1
|
作者：
Dornas, Waleska [1 ]
Silva, Maisa [2 ]
机构：
[1] Univ Fed Minas Gerais, Sch Med, Course Super Technol Radiol, Belo Horizonte, MG, Brazil
[2] Univ Fed Juiz De Fora, Dept Basic Life Sci, Governador Valadares, MG, Brazil
来源：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2024年 / 34卷 / 12期
关键词：
Paraoxonase; 1; Inflammation; Antioxidant response; Lipoperoxidation; HDL; Atherosclerosis; HIGH-DENSITY-LIPOPROTEIN; HIGH-FAT DIET; INCREASES SERUM PARAOXONASE; POMEGRANATE JUICE CONSUMPTION; CHOLESTEROL EFFLUX CAPACITY; C-REACTIVE PROTEIN; OXIDATIVE STRESS; GENE-EXPRESSION; PON1; GENE; LIPID-PEROXIDATION;
D O I：
10.1016/j.numecd.2024.04.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: The enzyme paraoxonase 1 (PON1) bound to high-density lipoprotein has received special attention for its protective role against stress-mediated damage and use as a potential regulatory target in atherosclerosis and related vascular diseases. Data synthesis: We present an overview of the literature on PON1 activity and mRNA levels by investigating its modulation for clinical translations. Specifically, the expression of PON1 and its regulated activity can be modified in different ways with natural substances, drugs, and lifestyle factors thar affect the development of atherosclerosis. Conclusions: The endothelial contribution of PON1 to overcome differences considering an individual's disease development risk is supported by polymorphism interaction data and the susceptibility to modify PON1 responses in chronic events composed by biological and environmental factors. (c) 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2611 / 2622
页数：12
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