One-Pot Synthesis of 3-Hydroxy-1H-Pyrrolo[3,4-b]quinolin-1-one via Enaminamides

被引：0
|
作者：
Shen, Xi [1 ]
Yu, Zhi-Cheng [1 ]
Zhou, You [1 ]
Wu, Yan-Dong [1 ]
Wu, An-Xin [1 ,2 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 21期
基金：
中国国家自然科学基金;
关键词：
Multicomponent cascade cyclization; Enaminamide reagents; One-pot; Good substrate compatibility; CHEMISTRY; BOND;
D O I：
10.1002/adsc.202400591
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A multicomponent cascade cyclization reaction using aryl methyl ketones, aryl amines, and enaminamide reagents to construct 3-hydroxy-1H-pyrrolo[3,4-b]quinolin-1-one skeleton with good substrate compatibility (50 examples) has been reported. The one-pot, metal-free process formed two C-C bonds, two C-N bonds, and a tetrasubstituted carbon stereocenter containing a hydroxyl group. The reaction enabled modified transformation of drug molecules and derivatization of products.
引用
收藏
页码：4399 / 4403
页数：5
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